Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression

Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and gutt...

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Autores principales:	Chang-Jin Jung, Hee-Joo Yang, Seung-Hyun Bang, Woo-Jin Lee, Chong-Hyun Won, Mi-Woo Lee, Youngsup Song, Sung-Eun Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psoriasis epidermal PD-1 dermal PD-1 immune checkpoint-related markers clinicoprognostic characteristics Medicine R
Acceso en línea:	https://doaj.org/article/4f18a4cbcaaa4b6c8402f7d37d668775
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spelling	oai:doaj.org-article:4f18a4cbcaaa4b6c8402f7d37d6687752021-11-11T17:48:23ZClinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression10.3390/jcm102152002077-0383https://doaj.org/article/4f18a4cbcaaa4b6c8402f7d37d6687752021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5200https://doaj.org/toc/2077-0383Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and guttate psoriasis (GP). Twenty-nine patients with skin biopsy-confirmed CPP were recruited at the Asan Medical Center between January 2018 and June 2020, and 33 patients with biopsy-confirmed GP were enrolled between January 2002 and June 2020. The clinicoprognostic and histopathological characteristics were analyzed according to immunohistochemical PD-1 expression in the epidermal or dermal inflammatory infiltrates. The CPP and GP lesions were divided into PD-1-low and PD-1-high groups. The CPP epidermal PD-1-high group had typical histopathological changes and significantly higher psoriasis area and severity index scores (<i>p</i> = 0.014) and disease duration (<i>p</i> = 0.009) than the epidermal PD-1-low group. In patients with GP, compared with the dermal PD-1-high group, the dermal PD-1-low group exhibited significantly higher disease duration (<i>p</i> = 0.002) and relapse rate of plaque psoriasis (<i>p</i> = 0.005) and significantly lower relapse-free survival (<i>p</i> = 0.016). Upregulated epidermal PD-1 expression was correlated with the chronicity and severity of CPP, while downregulated dermal PD-1 expression was correlated with poor prognosis of GP.Chang-Jin JungHee-Joo YangSeung-Hyun BangWoo-Jin LeeChong-Hyun WonMi-Woo LeeYoungsup SongSung-Eun ChangMDPI AGarticlepsoriasisepidermal PD-1dermal PD-1immune checkpoint-related markersclinicoprognostic characteristicsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5200, p 5200 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis epidermal PD-1 dermal PD-1 immune checkpoint-related markers clinicoprognostic characteristics Medicine R
spellingShingle	psoriasis epidermal PD-1 dermal PD-1 immune checkpoint-related markers clinicoprognostic characteristics Medicine R Chang-Jin Jung Hee-Joo Yang Seung-Hyun Bang Woo-Jin Lee Chong-Hyun Won Mi-Woo Lee Youngsup Song Sung-Eun Chang Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
description	Several studies have determined the correlation between programmed cell death protein-1 (PD-1) and chronic plaque psoriasis (CPP). However, limited studies have assessed the association between PD-1 expression and the clinicoprognostic and distinct clinicopathological characteristics of CPP and guttate psoriasis (GP). Twenty-nine patients with skin biopsy-confirmed CPP were recruited at the Asan Medical Center between January 2018 and June 2020, and 33 patients with biopsy-confirmed GP were enrolled between January 2002 and June 2020. The clinicoprognostic and histopathological characteristics were analyzed according to immunohistochemical PD-1 expression in the epidermal or dermal inflammatory infiltrates. The CPP and GP lesions were divided into PD-1-low and PD-1-high groups. The CPP epidermal PD-1-high group had typical histopathological changes and significantly higher psoriasis area and severity index scores (<i>p</i> = 0.014) and disease duration (<i>p</i> = 0.009) than the epidermal PD-1-low group. In patients with GP, compared with the dermal PD-1-high group, the dermal PD-1-low group exhibited significantly higher disease duration (<i>p</i> = 0.002) and relapse rate of plaque psoriasis (<i>p</i> = 0.005) and significantly lower relapse-free survival (<i>p</i> = 0.016). Upregulated epidermal PD-1 expression was correlated with the chronicity and severity of CPP, while downregulated dermal PD-1 expression was correlated with poor prognosis of GP.
format	article
author	Chang-Jin Jung Hee-Joo Yang Seung-Hyun Bang Woo-Jin Lee Chong-Hyun Won Mi-Woo Lee Youngsup Song Sung-Eun Chang
author_facet	Chang-Jin Jung Hee-Joo Yang Seung-Hyun Bang Woo-Jin Lee Chong-Hyun Won Mi-Woo Lee Youngsup Song Sung-Eun Chang
author_sort	Chang-Jin Jung
title	Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
title_short	Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
title_full	Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
title_fullStr	Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
title_full_unstemmed	Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
title_sort	clinicoprognostic and histopathological features of guttate and plaque psoriasis based on pd-1 expression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f18a4cbcaaa4b6c8402f7d37d668775
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Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression

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