CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION

Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifo...

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Autores principales:	N. N. Zhukova, M. V. Manzhos, L. R. Khabibulina, E. Yu. Syrtsova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	ragweed immunotherapy pollinosis trifida cytokines il-4 amb a 1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4f1dfe72e65643d1ae7c49effe157116
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spelling	oai:doaj.org-article:4f1dfe72e65643d1ae7c49effe1571162021-11-18T08:03:51ZCLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION1563-06252313-741X10.15789/1563-0625-CAI-2210https://doaj.org/article/4f1dfe72e65643d1ae7c49effe1571162021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2437https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAllergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifolia in patients sensitized to Ambrosia trifida in the Samara region. Patients with proven sensitization to Ambrosia trifida was held immunotherapy with Ambrosia artemisiifolia allergoid preseason. After treatment, patients had a decrease in the severity of symptoms of allergic rhinitis according to VAS (p = 0.00001), a decrease in the need for medications (p = 0.0003), as well as the need for corticosteroids against the background of therapy from 34.6% to 0% (p = 0.00001). In 8% of cases, the result of treatment was good, in 69% satisfactory, in 23% unsatisfactory. In the control group, there were no changes in the severity of symptoms (p = 0.858). Also, in the control group, the need for medications remained unchanged and 14.3% of patients continued to use corticosteroids.After ASIT, there was a decrease in the level of IL-4 (p = 0.002), and a decrease in the ratio of IL-4/ IL-10 (p = 0.0063); at the same time, changes in the level of other cytokines (IL-10; IFNγ) were statistically insignificant (p > 0.05). Before treatment, the levels of IL-4/ IL-10 in both groups were comparable, and after treatment, the differences became statistically significant (p = 0.031). We did not get a statistically significant change in the level of IgG4 Amb a 1 or IgG4 Amb trifida. There was no correlation between the level of individual cytokines and the results of treatment. As a result of the conducted ASIT, positive clinical and immunological results were obtained. In most patients, the disease has acquired a controlled course. At the same time, the lack of excellent and low number of good results of ASIT is probably due to the intraspecific allergenic properties of ragweed.N. N. ZhukovaM. V. ManzhosL. R. KhabibulinaE. Yu. SyrtsovaSPb RAACIarticleragweedimmunotherapypollinosistrifidacytokinesil-4amb a 1Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 921-926 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	ragweed immunotherapy pollinosis trifida cytokines il-4 amb a 1 Immunologic diseases. Allergy RC581-607
spellingShingle	ragweed immunotherapy pollinosis trifida cytokines il-4 amb a 1 Immunologic diseases. Allergy RC581-607 N. N. Zhukova M. V. Manzhos L. R. Khabibulina E. Yu. Syrtsova CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
description	Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed. The aim of the study was to evaluate the clinical and immunological efficacy of ASIT with the allergen Ambrosia artemisiifolia in patients sensitized to Ambrosia trifida in the Samara region. Patients with proven sensitization to Ambrosia trifida was held immunotherapy with Ambrosia artemisiifolia allergoid preseason. After treatment, patients had a decrease in the severity of symptoms of allergic rhinitis according to VAS (p = 0.00001), a decrease in the need for medications (p = 0.0003), as well as the need for corticosteroids against the background of therapy from 34.6% to 0% (p = 0.00001). In 8% of cases, the result of treatment was good, in 69% satisfactory, in 23% unsatisfactory. In the control group, there were no changes in the severity of symptoms (p = 0.858). Also, in the control group, the need for medications remained unchanged and 14.3% of patients continued to use corticosteroids.After ASIT, there was a decrease in the level of IL-4 (p = 0.002), and a decrease in the ratio of IL-4/ IL-10 (p = 0.0063); at the same time, changes in the level of other cytokines (IL-10; IFNγ) were statistically insignificant (p > 0.05). Before treatment, the levels of IL-4/ IL-10 in both groups were comparable, and after treatment, the differences became statistically significant (p = 0.031). We did not get a statistically significant change in the level of IgG4 Amb a 1 or IgG4 Amb trifida. There was no correlation between the level of individual cytokines and the results of treatment. As a result of the conducted ASIT, positive clinical and immunological results were obtained. In most patients, the disease has acquired a controlled course. At the same time, the lack of excellent and low number of good results of ASIT is probably due to the intraspecific allergenic properties of ragweed.
format	article
author	N. N. Zhukova M. V. Manzhos L. R. Khabibulina E. Yu. Syrtsova
author_facet	N. N. Zhukova M. V. Manzhos L. R. Khabibulina E. Yu. Syrtsova
author_sort	N. N. Zhukova
title	CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
title_short	CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
title_full	CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
title_fullStr	CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
title_full_unstemmed	CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
title_sort	clinical and immunological effectiveness of treatment of ragweed pollinosis in the samara region
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/4f1dfe72e65643d1ae7c49effe157116
work_keys_str_mv	AT nnzhukova clinicalandimmunologicaleffectivenessoftreatmentofragweedpollinosisinthesamararegion AT mvmanzhos clinicalandimmunologicaleffectivenessoftreatmentofragweedpollinosisinthesamararegion AT lrkhabibulina clinicalandimmunologicaleffectivenessoftreatmentofragweedpollinosisinthesamararegion AT eyusyrtsova clinicalandimmunologicaleffectivenessoftreatmentofragweedpollinosisinthesamararegion
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CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION

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