Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from reco...

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Autores principales:	Liwei Cao, Matthias Pauthner, Raiees Andrabi, Kimmo Rantalainen, Zachary Berndsen, Jolene K. Diedrich, Sergey Menis, Devin Sok, Raiza Bastidas, Sung-Kyu Robin Park, Claire M. Delahunty, Lin He, Javier Guenaga, Richard T. Wyatt, William R. Schief, Andrew B. Ward, John R. Yates, Dennis R. Burton, James C. Paulson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f20b420b7274e21b3fd2be2a1aa131b
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spelling	oai:doaj.org-article:4f20b420b7274e21b3fd2be2a1aa131b2021-12-02T16:50:11ZDifferential processing of HIV envelope glycans on the virus and soluble recombinant trimer10.1038/s41467-018-06121-42041-1723https://doaj.org/article/4f20b420b7274e21b3fd2be2a1aa131b2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06121-4https://doaj.org/toc/2041-1723HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.Liwei CaoMatthias PauthnerRaiees AndrabiKimmo RantalainenZachary BerndsenJolene K. DiedrichSergey MenisDevin SokRaiza BastidasSung-Kyu Robin ParkClaire M. DelahuntyLin HeJavier GuenagaRichard T. WyattWilliam R. SchiefAndrew B. WardJohn R. YatesDennis R. BurtonJames C. PaulsonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liwei Cao Matthias Pauthner Raiees Andrabi Kimmo Rantalainen Zachary Berndsen Jolene K. Diedrich Sergey Menis Devin Sok Raiza Bastidas Sung-Kyu Robin Park Claire M. Delahunty Lin He Javier Guenaga Richard T. Wyatt William R. Schief Andrew B. Ward John R. Yates Dennis R. Burton James C. Paulson Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
description	HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers.
format	article
author	Liwei Cao Matthias Pauthner Raiees Andrabi Kimmo Rantalainen Zachary Berndsen Jolene K. Diedrich Sergey Menis Devin Sok Raiza Bastidas Sung-Kyu Robin Park Claire M. Delahunty Lin He Javier Guenaga Richard T. Wyatt William R. Schief Andrew B. Ward John R. Yates Dennis R. Burton James C. Paulson
author_facet	Liwei Cao Matthias Pauthner Raiees Andrabi Kimmo Rantalainen Zachary Berndsen Jolene K. Diedrich Sergey Menis Devin Sok Raiza Bastidas Sung-Kyu Robin Park Claire M. Delahunty Lin He Javier Guenaga Richard T. Wyatt William R. Schief Andrew B. Ward John R. Yates Dennis R. Burton James C. Paulson
author_sort	Liwei Cao
title	Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
title_short	Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
title_full	Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
title_fullStr	Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
title_full_unstemmed	Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
title_sort	differential processing of hiv envelope glycans on the virus and soluble recombinant trimer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4f20b420b7274e21b3fd2be2a1aa131b
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Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

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