Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins

Bacterial gut communities might predispose children to develop asthma. Yet, little is known about the role of these micro-organisms in adult asthmatics. We aimed to profile the relationship between fecal microbiota and asthma in a large-scale, ethnically diverse, observational cohort of adults. Feca...

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Autores principales:	Robert F. J. Kullberg, Bastiaan W. Haak, Mahmoud I. Abdel-Aziz, Mark Davids, Floor Hugenholtz, Max Nieuwdorp, Henrike Galenkamp, Maria Prins, Anke H. Maitland-van der Zee, W. Joost Wiersinga
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	asthma microbiome bacterial community composition gastrointestinal tract adults ethnicity helius study Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/4f24724ebb144da699044e2232943a6e
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spelling	oai:doaj.org-article:4f24724ebb144da699044e2232943a6e2021-11-11T14:23:42ZGut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins1949-09761949-098410.1080/19490976.2021.1995279https://doaj.org/article/4f24724ebb144da699044e2232943a6e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1995279https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Bacterial gut communities might predispose children to develop asthma. Yet, little is known about the role of these micro-organisms in adult asthmatics. We aimed to profile the relationship between fecal microbiota and asthma in a large-scale, ethnically diverse, observational cohort of adults. Fecal microbiota composition of 1632 adults (172 asthmatics and 1460 non-asthmatics) was analyzed using 16S ribosomal RNA gene sequencing. Using extremely randomized trees machine learning models, we assessed the discriminatory ability of gut bacterial features to identify asthmatics from non-asthmatics. Asthma contributed 0.019% to interindividual dissimilarities in intestinal microbiota composition, which was not significant (P = .97). Asthmatics could not be distinguished from non-asthmatics based on individual microbiota composition by an extremely randomized trees classifier model (area under the receiver operating characteristic curve = 0.54). In conclusion, there were no prominent differences in fecal microbiota composition in adult asthmatics when compared to non-asthmatics in an urban, large-sized and ethnically diverse cohort.Robert F. J. KullbergBastiaan W. HaakMahmoud I. Abdel-AzizMark DavidsFloor HugenholtzMax NieuwdorpHenrike GalenkampMaria PrinsAnke H. Maitland-van der ZeeW. Joost WiersingaTaylor & Francis Grouparticleasthmamicrobiomebacterial community compositiongastrointestinal tractadultsethnicityhelius studyDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthma microbiome bacterial community composition gastrointestinal tract adults ethnicity helius study Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	asthma microbiome bacterial community composition gastrointestinal tract adults ethnicity helius study Diseases of the digestive system. Gastroenterology RC799-869 Robert F. J. Kullberg Bastiaan W. Haak Mahmoud I. Abdel-Aziz Mark Davids Floor Hugenholtz Max Nieuwdorp Henrike Galenkamp Maria Prins Anke H. Maitland-van der Zee W. Joost Wiersinga Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
description	Bacterial gut communities might predispose children to develop asthma. Yet, little is known about the role of these micro-organisms in adult asthmatics. We aimed to profile the relationship between fecal microbiota and asthma in a large-scale, ethnically diverse, observational cohort of adults. Fecal microbiota composition of 1632 adults (172 asthmatics and 1460 non-asthmatics) was analyzed using 16S ribosomal RNA gene sequencing. Using extremely randomized trees machine learning models, we assessed the discriminatory ability of gut bacterial features to identify asthmatics from non-asthmatics. Asthma contributed 0.019% to interindividual dissimilarities in intestinal microbiota composition, which was not significant (P = .97). Asthmatics could not be distinguished from non-asthmatics based on individual microbiota composition by an extremely randomized trees classifier model (area under the receiver operating characteristic curve = 0.54). In conclusion, there were no prominent differences in fecal microbiota composition in adult asthmatics when compared to non-asthmatics in an urban, large-sized and ethnically diverse cohort.
format	article
author	Robert F. J. Kullberg Bastiaan W. Haak Mahmoud I. Abdel-Aziz Mark Davids Floor Hugenholtz Max Nieuwdorp Henrike Galenkamp Maria Prins Anke H. Maitland-van der Zee W. Joost Wiersinga
author_facet	Robert F. J. Kullberg Bastiaan W. Haak Mahmoud I. Abdel-Aziz Mark Davids Floor Hugenholtz Max Nieuwdorp Henrike Galenkamp Maria Prins Anke H. Maitland-van der Zee W. Joost Wiersinga
author_sort	Robert F. J. Kullberg
title	Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
title_short	Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
title_full	Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
title_fullStr	Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
title_full_unstemmed	Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
title_sort	gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/4f24724ebb144da699044e2232943a6e
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Gut microbiota of adults with asthma is broadly similar to non-asthmatics in a large population with varied ethnic origins

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