Complexity of genetic mechanisms conferring nonuniformity of recombination in maize

Abstract Recombinations occur nonuniformly across the maize genome. To dissect the genetic mechanisms underlying the nonuniformity of recombination, we performed quantitative trait locus (QTL) mapping using recombinant inbred line populations. Genome-wide QTL scan identified hundreds of QTLs with bo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qingchun Pan, Min Deng, Jianbing Yan, Lin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f247dc98e1545a8a762509bb0b13dd5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f247dc98e1545a8a762509bb0b13dd5
record_format	dspace
spelling	oai:doaj.org-article:4f247dc98e1545a8a762509bb0b13dd52021-12-02T11:52:29ZComplexity of genetic mechanisms conferring nonuniformity of recombination in maize10.1038/s41598-017-01240-22045-2322https://doaj.org/article/4f247dc98e1545a8a762509bb0b13dd52017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01240-2https://doaj.org/toc/2045-2322Abstract Recombinations occur nonuniformly across the maize genome. To dissect the genetic mechanisms underlying the nonuniformity of recombination, we performed quantitative trait locus (QTL) mapping using recombinant inbred line populations. Genome-wide QTL scan identified hundreds of QTLs with both cis-prone and trans- effects for recombination number variation. To provide detailed insights into cis- factors associated with recombination variation, we examined the genomic features around recombination hot regions, including density of genes, DNA transposons, retrotransposons, and some specific motifs. Compared to recombination variation in whole genome, more QTLs were mapped for variations in recombination hot regions. The majority QTLs for recombination hot regions are trans-QTLs and co-localized with genes from the recombination pathway. We also found that recombination variation was positively associated with the presence of genes and DNA transposons, but negatively related to the presence of long terminal repeat retrotransposons. Additionally, 41 recombination hot regions were fine-mapped. The high-resolution genotyping of five randomly selected regions in two F2 populations verified that they indeed have ultra-high recombination frequency, which is even higher than that of the well-known recombination hot regions sh1-bz and a1-sh2. Taken together, our results further our understanding of recombination variation in plants.Qingchun PanMin DengJianbing YanLin LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qingchun Pan Min Deng Jianbing Yan Lin Li Complexity of genetic mechanisms conferring nonuniformity of recombination in maize
description	Abstract Recombinations occur nonuniformly across the maize genome. To dissect the genetic mechanisms underlying the nonuniformity of recombination, we performed quantitative trait locus (QTL) mapping using recombinant inbred line populations. Genome-wide QTL scan identified hundreds of QTLs with both cis-prone and trans- effects for recombination number variation. To provide detailed insights into cis- factors associated with recombination variation, we examined the genomic features around recombination hot regions, including density of genes, DNA transposons, retrotransposons, and some specific motifs. Compared to recombination variation in whole genome, more QTLs were mapped for variations in recombination hot regions. The majority QTLs for recombination hot regions are trans-QTLs and co-localized with genes from the recombination pathway. We also found that recombination variation was positively associated with the presence of genes and DNA transposons, but negatively related to the presence of long terminal repeat retrotransposons. Additionally, 41 recombination hot regions were fine-mapped. The high-resolution genotyping of five randomly selected regions in two F2 populations verified that they indeed have ultra-high recombination frequency, which is even higher than that of the well-known recombination hot regions sh1-bz and a1-sh2. Taken together, our results further our understanding of recombination variation in plants.
format	article
author	Qingchun Pan Min Deng Jianbing Yan Lin Li
author_facet	Qingchun Pan Min Deng Jianbing Yan Lin Li
author_sort	Qingchun Pan
title	Complexity of genetic mechanisms conferring nonuniformity of recombination in maize
title_short	Complexity of genetic mechanisms conferring nonuniformity of recombination in maize
title_full	Complexity of genetic mechanisms conferring nonuniformity of recombination in maize
title_fullStr	Complexity of genetic mechanisms conferring nonuniformity of recombination in maize
title_full_unstemmed	Complexity of genetic mechanisms conferring nonuniformity of recombination in maize
title_sort	complexity of genetic mechanisms conferring nonuniformity of recombination in maize
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4f247dc98e1545a8a762509bb0b13dd5
work_keys_str_mv	AT qingchunpan complexityofgeneticmechanismsconferringnonuniformityofrecombinationinmaize AT mindeng complexityofgeneticmechanismsconferringnonuniformityofrecombinationinmaize AT jianbingyan complexityofgeneticmechanismsconferringnonuniformityofrecombinationinmaize AT linli complexityofgeneticmechanismsconferringnonuniformityofrecombinationinmaize
_version_	1718395046191955968

Complexity of genetic mechanisms conferring nonuniformity of recombination in maize

Ejemplares similares