Variability in Global Prevalence of Interstitial Lung Disease

There are limited epidemiologic studies describing the global burden and geographic heterogeneity of interstitial lung disease (ILD) subtypes. We found that among seventeen methodologically heterogenous studies that examined the incidence, prevalence and relative frequencies of ILDs, the incidence o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bhavika Kaul, Vincent Cottin, Harold R. Collard, Claudia Valenzuela
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	interstitial lung disease epidemiology—descriptive global epidemiology idiopathic pulmonary fibrosis mortality Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4f2e0040a6cb4717983959c6a0350add
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f2e0040a6cb4717983959c6a0350add
record_format	dspace
spelling	oai:doaj.org-article:4f2e0040a6cb4717983959c6a0350add2021-11-04T05:25:21ZVariability in Global Prevalence of Interstitial Lung Disease2296-858X10.3389/fmed.2021.751181https://doaj.org/article/4f2e0040a6cb4717983959c6a0350add2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.751181/fullhttps://doaj.org/toc/2296-858XThere are limited epidemiologic studies describing the global burden and geographic heterogeneity of interstitial lung disease (ILD) subtypes. We found that among seventeen methodologically heterogenous studies that examined the incidence, prevalence and relative frequencies of ILDs, the incidence of ILD ranged from 1 to 31.5 per 100,000 person-years and prevalence ranged from 6.3 to 71 per 100,000 people. In North America and Europe, idiopathic pulmonary fibrosis and sarcoidosis were the most prevalent ILDs while the relative frequency of hypersensitivity pneumonitis was higher in Asia, particularly in India (10.7–47.3%) and Pakistan (12.6%). The relative frequency of connective tissue disease ILD demonstrated the greatest geographic variability, ranging from 7.5% of cases in Belgium to 33.3% of cases in Canada and 34.8% of cases in Saudi Arabia. These differences may represent true differences based on underlying characteristics of the source populations or methodological differences in disease classification and patient recruitment (registry vs. population-based cohorts). There are three areas where we feel addition work is needed to better understand the global burden of ILD. First, a standard ontology with diagnostic confidence thresholds for comparative epidemiology studies of ILD is needed. Second, more globally representative data should be published in English language journals as current literature has largely focused on Europe and North America with little data from South America, Africa and Asia. Third, the inclusion of community-based cohorts that leverage the strength of large databases can help better estimate population burden of disease. These large, community-based longitudinal cohorts would also allow for tracking of global trends and be a valuable resource for collective study. We believe the ILD research community should organize to define a shared ontology for disease classification and commit to conducting global claims and electronic health record based epidemiologic studies in a standardized fashion. Aggregating and sharing this type of data would provide a unique opportunity for international collaboration as our understanding of ILD continues to grow and evolve. Better understanding the geographic and temporal patterns of disease prevalence and identifying clusters of ILD subtypes will facilitate improved understanding of emerging risk factors and help identify targets for future intervention.Bhavika KaulVincent CottinVincent CottinHarold R. CollardClaudia ValenzuelaFrontiers Media S.A.articleinterstitial lung diseaseepidemiology—descriptiveglobal epidemiologyidiopathic pulmonary fibrosismortalityMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interstitial lung disease epidemiology—descriptive global epidemiology idiopathic pulmonary fibrosis mortality Medicine (General) R5-920
spellingShingle	interstitial lung disease epidemiology—descriptive global epidemiology idiopathic pulmonary fibrosis mortality Medicine (General) R5-920 Bhavika Kaul Vincent Cottin Vincent Cottin Harold R. Collard Claudia Valenzuela Variability in Global Prevalence of Interstitial Lung Disease
description	There are limited epidemiologic studies describing the global burden and geographic heterogeneity of interstitial lung disease (ILD) subtypes. We found that among seventeen methodologically heterogenous studies that examined the incidence, prevalence and relative frequencies of ILDs, the incidence of ILD ranged from 1 to 31.5 per 100,000 person-years and prevalence ranged from 6.3 to 71 per 100,000 people. In North America and Europe, idiopathic pulmonary fibrosis and sarcoidosis were the most prevalent ILDs while the relative frequency of hypersensitivity pneumonitis was higher in Asia, particularly in India (10.7–47.3%) and Pakistan (12.6%). The relative frequency of connective tissue disease ILD demonstrated the greatest geographic variability, ranging from 7.5% of cases in Belgium to 33.3% of cases in Canada and 34.8% of cases in Saudi Arabia. These differences may represent true differences based on underlying characteristics of the source populations or methodological differences in disease classification and patient recruitment (registry vs. population-based cohorts). There are three areas where we feel addition work is needed to better understand the global burden of ILD. First, a standard ontology with diagnostic confidence thresholds for comparative epidemiology studies of ILD is needed. Second, more globally representative data should be published in English language journals as current literature has largely focused on Europe and North America with little data from South America, Africa and Asia. Third, the inclusion of community-based cohorts that leverage the strength of large databases can help better estimate population burden of disease. These large, community-based longitudinal cohorts would also allow for tracking of global trends and be a valuable resource for collective study. We believe the ILD research community should organize to define a shared ontology for disease classification and commit to conducting global claims and electronic health record based epidemiologic studies in a standardized fashion. Aggregating and sharing this type of data would provide a unique opportunity for international collaboration as our understanding of ILD continues to grow and evolve. Better understanding the geographic and temporal patterns of disease prevalence and identifying clusters of ILD subtypes will facilitate improved understanding of emerging risk factors and help identify targets for future intervention.
format	article
author	Bhavika Kaul Vincent Cottin Vincent Cottin Harold R. Collard Claudia Valenzuela
author_facet	Bhavika Kaul Vincent Cottin Vincent Cottin Harold R. Collard Claudia Valenzuela
author_sort	Bhavika Kaul
title	Variability in Global Prevalence of Interstitial Lung Disease
title_short	Variability in Global Prevalence of Interstitial Lung Disease
title_full	Variability in Global Prevalence of Interstitial Lung Disease
title_fullStr	Variability in Global Prevalence of Interstitial Lung Disease
title_full_unstemmed	Variability in Global Prevalence of Interstitial Lung Disease
title_sort	variability in global prevalence of interstitial lung disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4f2e0040a6cb4717983959c6a0350add
work_keys_str_mv	AT bhavikakaul variabilityinglobalprevalenceofinterstitiallungdisease AT vincentcottin variabilityinglobalprevalenceofinterstitiallungdisease AT vincentcottin variabilityinglobalprevalenceofinterstitiallungdisease AT haroldrcollard variabilityinglobalprevalenceofinterstitiallungdisease AT claudiavalenzuela variabilityinglobalprevalenceofinterstitiallungdisease
_version_	1718445207474667520

Variability in Global Prevalence of Interstitial Lung Disease

Ejemplares similares