Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression

Migraine and major depression are debilitating disorders with high lifetime prevalence rates. Interestingly these disorders are highly comorbid and show significant heritability, suggesting shared pathophysiological mechanisms. Non-homeostatic function of ion channels and neuroinflammation may be co...

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Autores principales:	Emine Eren-Koçak, Turgay Dalkara
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ATP1A2 HCN KCNQ CACNA TREK Pannnexin-1 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/4f2ec3ab479e48b6846a98e42fe8a2c0
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spelling	oai:doaj.org-article:4f2ec3ab479e48b6846a98e42fe8a2c02021-11-10T07:41:13ZIon Channel Dysfunction and Neuroinflammation in Migraine and Depression1663-981210.3389/fphar.2021.777607https://doaj.org/article/4f2ec3ab479e48b6846a98e42fe8a2c02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.777607/fullhttps://doaj.org/toc/1663-9812Migraine and major depression are debilitating disorders with high lifetime prevalence rates. Interestingly these disorders are highly comorbid and show significant heritability, suggesting shared pathophysiological mechanisms. Non-homeostatic function of ion channels and neuroinflammation may be common mechanisms underlying both disorders: The excitation-inhibition balance of microcircuits and their modulation by monoaminergic systems, which depend on the expression and function of membrane located K+, Na+, and Ca+2 channels, have been reported to be disturbed in both depression and migraine. Ion channels and energy supply to synapses not only change excitability of neurons but can also mediate the induction and maintenance of inflammatory signaling implicated in the pathophysiology of both disorders. In this respect, Pannexin-1 and P2X7 large-pore ion channel receptors can induce inflammasome formation that triggers release of pro-inflammatory mediators from the cell. Here, the role of ion channels involved in the regulation of excitation-inhibition balance, synaptic energy homeostasis as well as inflammatory signaling in migraine and depression will be reviewed.Emine Eren-KoçakEmine Eren-KoçakTurgay DalkaraFrontiers Media S.A.articleATP1A2HCNKCNQCACNATREKPannnexin-1Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ATP1A2 HCN KCNQ CACNA TREK Pannnexin-1 Therapeutics. Pharmacology RM1-950
spellingShingle	ATP1A2 HCN KCNQ CACNA TREK Pannnexin-1 Therapeutics. Pharmacology RM1-950 Emine Eren-Koçak Emine Eren-Koçak Turgay Dalkara Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
description	Migraine and major depression are debilitating disorders with high lifetime prevalence rates. Interestingly these disorders are highly comorbid and show significant heritability, suggesting shared pathophysiological mechanisms. Non-homeostatic function of ion channels and neuroinflammation may be common mechanisms underlying both disorders: The excitation-inhibition balance of microcircuits and their modulation by monoaminergic systems, which depend on the expression and function of membrane located K+, Na+, and Ca+2 channels, have been reported to be disturbed in both depression and migraine. Ion channels and energy supply to synapses not only change excitability of neurons but can also mediate the induction and maintenance of inflammatory signaling implicated in the pathophysiology of both disorders. In this respect, Pannexin-1 and P2X7 large-pore ion channel receptors can induce inflammasome formation that triggers release of pro-inflammatory mediators from the cell. Here, the role of ion channels involved in the regulation of excitation-inhibition balance, synaptic energy homeostasis as well as inflammatory signaling in migraine and depression will be reviewed.
format	article
author	Emine Eren-Koçak Emine Eren-Koçak Turgay Dalkara
author_facet	Emine Eren-Koçak Emine Eren-Koçak Turgay Dalkara
author_sort	Emine Eren-Koçak
title	Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
title_short	Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
title_full	Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
title_fullStr	Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
title_full_unstemmed	Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
title_sort	ion channel dysfunction and neuroinflammation in migraine and depression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4f2ec3ab479e48b6846a98e42fe8a2c0
work_keys_str_mv	AT emineerenkocak ionchanneldysfunctionandneuroinflammationinmigraineanddepression AT emineerenkocak ionchanneldysfunctionandneuroinflammationinmigraineanddepression AT turgaydalkara ionchanneldysfunctionandneuroinflammationinmigraineanddepression
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Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression

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