The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis

Perivascular adipose tissue (PVAT) is an additional special type of adipose tissue surrounding blood vessels. Under physiological conditions, PVAT plays a significant role in regulation of vascular tone, intravascular thermoregulation, and vascular smooth muscle cell (VSMC) proliferation. PVAT is re...

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Autores principales:	Agata Stanek, Klaudia Brożyna-Tkaczyk, Wojciech Myśliński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity perivascular adipose tissue exercise endothelial dysfunction Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/4f3120a518054b199363f734200da326
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spelling	oai:doaj.org-article:4f3120a518054b199363f734200da3262021-11-25T18:34:35ZThe Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis10.3390/nu131138432072-6643https://doaj.org/article/4f3120a518054b199363f734200da3262021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3843https://doaj.org/toc/2072-6643Perivascular adipose tissue (PVAT) is an additional special type of adipose tissue surrounding blood vessels. Under physiological conditions, PVAT plays a significant role in regulation of vascular tone, intravascular thermoregulation, and vascular smooth muscle cell (VSMC) proliferation. PVAT is responsible for releasing adipocytes-derived relaxing factors (ADRF) and perivascular-derived relaxing factors (PDRF), which have anticontractile properties. Obesity induces increased oxidative stress, an inflammatory state, and hypoxia, which contribute to PVAT dysfunction. The exact mechanism of vascular dysfunction in obesity is still not well clarified; however, there are some pathways such as renin–angiotensin–aldosterone system (RAAS) disorders and PVAT-derived factor dysregulation, which are involved in hypertension and endothelial dysfunction development. Physical activity has a beneficial effect on PVAT function among obese patients by reducing the oxidative stress and inflammatory state. Diet, which is the second most beneficial non-invasive strategy in obesity treatment, may have a positive impact on PVAT-derived factors and may restore the balance in their concentration.Agata StanekKlaudia Brożyna-TkaczykWojciech MyślińskiMDPI AGarticleobesityperivascular adipose tissueexerciseendothelial dysfunctionNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3843, p 3843 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity perivascular adipose tissue exercise endothelial dysfunction Nutrition. Foods and food supply TX341-641
spellingShingle	obesity perivascular adipose tissue exercise endothelial dysfunction Nutrition. Foods and food supply TX341-641 Agata Stanek Klaudia Brożyna-Tkaczyk Wojciech Myśliński The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
description	Perivascular adipose tissue (PVAT) is an additional special type of adipose tissue surrounding blood vessels. Under physiological conditions, PVAT plays a significant role in regulation of vascular tone, intravascular thermoregulation, and vascular smooth muscle cell (VSMC) proliferation. PVAT is responsible for releasing adipocytes-derived relaxing factors (ADRF) and perivascular-derived relaxing factors (PDRF), which have anticontractile properties. Obesity induces increased oxidative stress, an inflammatory state, and hypoxia, which contribute to PVAT dysfunction. The exact mechanism of vascular dysfunction in obesity is still not well clarified; however, there are some pathways such as renin–angiotensin–aldosterone system (RAAS) disorders and PVAT-derived factor dysregulation, which are involved in hypertension and endothelial dysfunction development. Physical activity has a beneficial effect on PVAT function among obese patients by reducing the oxidative stress and inflammatory state. Diet, which is the second most beneficial non-invasive strategy in obesity treatment, may have a positive impact on PVAT-derived factors and may restore the balance in their concentration.
format	article
author	Agata Stanek Klaudia Brożyna-Tkaczyk Wojciech Myśliński
author_facet	Agata Stanek Klaudia Brożyna-Tkaczyk Wojciech Myśliński
author_sort	Agata Stanek
title	The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
title_short	The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
title_full	The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
title_fullStr	The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
title_full_unstemmed	The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
title_sort	role of obesity-induced perivascular adipose tissue (pvat) dysfunction in vascular homeostasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f3120a518054b199363f734200da326
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The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis

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