MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks

Abstract DNA methylation (DNAm) alterations have been heavily implicated in carcinogenesis and the pathophysiology of diseases through upstream regulation of gene expression. DNAm deep-learning approaches are able to capture features associated with aging, cell type, and disease progression, but lac...

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Autores principales: Joshua J. Levy, Youdinghuan Chen, Nasim Azizgolshani, Curtis L. Petersen, Alexander J. Titus, Erika L. Moen, Louis J. Vaickus, Lucas A. Salas, Brock C. Christensen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4f32c8343c1846d98fa3b43cf8e3aca6
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