Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.

Recently, there has been a renewed interest in low-field MRI. Contrast agents (CA) in MRI have magnetic behavior dependent on magnetic field strength. Therefore, the optimal contrast agent for low-field MRI might be different from what is used at higher fields. Ultra-small superparamagnetic iron-oxi...

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Autores principales:	Jordy K van Zandwijk, Frank F J Simonis, Friso G Heslinga, Elfi I S Hofmeijer, Robert H Geelkerken, Bennie Ten Haken
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f3402e4a57044098b77329ac482f9cd
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spelling	oai:doaj.org-article:4f3402e4a57044098b77329ac482f9cd2021-12-02T20:17:55ZComparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.1932-620310.1371/journal.pone.0256252https://doaj.org/article/4f3402e4a57044098b77329ac482f9cd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256252https://doaj.org/toc/1932-6203Recently, there has been a renewed interest in low-field MRI. Contrast agents (CA) in MRI have magnetic behavior dependent on magnetic field strength. Therefore, the optimal contrast agent for low-field MRI might be different from what is used at higher fields. Ultra-small superparamagnetic iron-oxides (USPIOs), commonly used as negative CA, might also be used for generating positive contrast in low-field MRI. The purpose of this study was to determine whether an USPIO or a gadolinium based contrast agent is more appropriate at low field strengths. Relaxivity values of ferumoxytol (USPIO) and gadoterate (gadolinium based) were used in this research to simulate normalized signal intensity (SI) curves within a concentration range of 0-15 mM. Simulations were experimentally validated on a 0.25T MRI scanner. Simulations and experiments were performed using spin echo (SE), spoiled gradient echo (SGE), and balanced steady-state free precession (bSSFP) sequences. Maximum achievable SIs were assessed for both CAs in a range of concentrations on all sequences. Simulations at 0.25T showed a peak in SIs at low concentrations ferumoxytol versus a wide top at higher concentrations for gadoterate in SE and SGE. Experiments agreed well with the simulations in SE and SGE, but less in the bSSFP sequence due to overestimated relaxivities in simulations. At low magnetic field strengths, ferumoxytol generates similar signal enhancement at lower concentrations than gadoterate.Jordy K van ZandwijkFrank F J SimonisFriso G HeslingaElfi I S HofmeijerRobert H GeelkerkenBennie Ten HakenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256252 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jordy K van Zandwijk Frank F J Simonis Friso G Heslinga Elfi I S Hofmeijer Robert H Geelkerken Bennie Ten Haken Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.
description	Recently, there has been a renewed interest in low-field MRI. Contrast agents (CA) in MRI have magnetic behavior dependent on magnetic field strength. Therefore, the optimal contrast agent for low-field MRI might be different from what is used at higher fields. Ultra-small superparamagnetic iron-oxides (USPIOs), commonly used as negative CA, might also be used for generating positive contrast in low-field MRI. The purpose of this study was to determine whether an USPIO or a gadolinium based contrast agent is more appropriate at low field strengths. Relaxivity values of ferumoxytol (USPIO) and gadoterate (gadolinium based) were used in this research to simulate normalized signal intensity (SI) curves within a concentration range of 0-15 mM. Simulations were experimentally validated on a 0.25T MRI scanner. Simulations and experiments were performed using spin echo (SE), spoiled gradient echo (SGE), and balanced steady-state free precession (bSSFP) sequences. Maximum achievable SIs were assessed for both CAs in a range of concentrations on all sequences. Simulations at 0.25T showed a peak in SIs at low concentrations ferumoxytol versus a wide top at higher concentrations for gadoterate in SE and SGE. Experiments agreed well with the simulations in SE and SGE, but less in the bSSFP sequence due to overestimated relaxivities in simulations. At low magnetic field strengths, ferumoxytol generates similar signal enhancement at lower concentrations than gadoterate.
format	article
author	Jordy K van Zandwijk Frank F J Simonis Friso G Heslinga Elfi I S Hofmeijer Robert H Geelkerken Bennie Ten Haken
author_facet	Jordy K van Zandwijk Frank F J Simonis Friso G Heslinga Elfi I S Hofmeijer Robert H Geelkerken Bennie Ten Haken
author_sort	Jordy K van Zandwijk
title	Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.
title_short	Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.
title_full	Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.
title_fullStr	Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.
title_full_unstemmed	Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.
title_sort	comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field mri.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/4f3402e4a57044098b77329ac482f9cd
work_keys_str_mv	AT jordykvanzandwijk comparingthesignalenhancementofagadoliniumbasedandanironoxidebasedcontrastagentinlowfieldmri AT frankfjsimonis comparingthesignalenhancementofagadoliniumbasedandanironoxidebasedcontrastagentinlowfieldmri AT frisogheslinga comparingthesignalenhancementofagadoliniumbasedandanironoxidebasedcontrastagentinlowfieldmri AT elfiishofmeijer comparingthesignalenhancementofagadoliniumbasedandanironoxidebasedcontrastagentinlowfieldmri AT roberthgeelkerken comparingthesignalenhancementofagadoliniumbasedandanironoxidebasedcontrastagentinlowfieldmri AT bennietenhaken comparingthesignalenhancementofagadoliniumbasedandanironoxidebasedcontrastagentinlowfieldmri
_version_	1718374342589415424

Comparing the signal enhancement of a gadolinium based and an iron-oxide based contrast agent in low-field MRI.

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