Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study

Abstract Background Pilot studies are essential in determining if a larger study is feasible. This is especially true when targeting populations that experience stigma and may be difficult to include in research, such as people with HIV. We sought to describe how pilot studies have been used to info...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hussein Ali El-Khechen, Mohammed Inam Ullah Khan, Selvin Leenus, Oluwatobi Olaiya, Zoha Durrani, Zaryan Masood, Alvin Leenus, Shakib Akhter, Lawrence Mbuagbaw
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pilot study Feasibility study Feasibility outcome Progression criteria Key population HIV Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4f3742647e244e7291bf3caeb40843dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f3742647e244e7291bf3caeb40843dd
record_format	dspace
spelling	oai:doaj.org-article:4f3742647e244e7291bf3caeb40843dd2021-12-05T12:08:30ZDesign, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study10.1186/s40814-021-00934-92055-5784https://doaj.org/article/4f3742647e244e7291bf3caeb40843dd2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40814-021-00934-9https://doaj.org/toc/2055-5784Abstract Background Pilot studies are essential in determining if a larger study is feasible. This is especially true when targeting populations that experience stigma and may be difficult to include in research, such as people with HIV. We sought to describe how pilot studies have been used to inform HIV clinical trials. Methods We conducted a methodological study of pilot studies of interventions in people living with HIV published until November 25, 2020, using Medline, Embase, and Cochrane Controlled Register of Trials (CENTRAL). We extracted data on their nomenclature, primary objective, use of progression criteria, sample size, use of qualitative methods, and other contextual information (region, income, level, type of intervention, study design). Results Our search retrieved 10,597 studies, of which 248 were eligible. The number of pilot studies increased steadily over time. We found that 179 studies (72.2%) used the terms “pilot” or “feasibility” in their title, 65.3% tested feasibility as a primary objective, only 2% used progression criteria, 23.9% provided a sample size estimation and only 30.2% used qualitative methods. Conclusions Pilot studies are increasingly being used to inform HIV research. However, the titles and objectives are not always consistent with piloting. The design and reporting of pilot studies in HIV could be improved.Hussein Ali El-KhechenMohammed Inam Ullah KhanSelvin LeenusOluwatobi OlaiyaZoha DurraniZaryan MasoodAlvin LeenusShakib AkhterLawrence MbuagbawBMCarticlePilot studyFeasibility studyFeasibility outcomeProgression criteriaKey populationHIVMedicine (General)R5-920ENPilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pilot study Feasibility study Feasibility outcome Progression criteria Key population HIV Medicine (General) R5-920
spellingShingle	Pilot study Feasibility study Feasibility outcome Progression criteria Key population HIV Medicine (General) R5-920 Hussein Ali El-Khechen Mohammed Inam Ullah Khan Selvin Leenus Oluwatobi Olaiya Zoha Durrani Zaryan Masood Alvin Leenus Shakib Akhter Lawrence Mbuagbaw Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study
description	Abstract Background Pilot studies are essential in determining if a larger study is feasible. This is especially true when targeting populations that experience stigma and may be difficult to include in research, such as people with HIV. We sought to describe how pilot studies have been used to inform HIV clinical trials. Methods We conducted a methodological study of pilot studies of interventions in people living with HIV published until November 25, 2020, using Medline, Embase, and Cochrane Controlled Register of Trials (CENTRAL). We extracted data on their nomenclature, primary objective, use of progression criteria, sample size, use of qualitative methods, and other contextual information (region, income, level, type of intervention, study design). Results Our search retrieved 10,597 studies, of which 248 were eligible. The number of pilot studies increased steadily over time. We found that 179 studies (72.2%) used the terms “pilot” or “feasibility” in their title, 65.3% tested feasibility as a primary objective, only 2% used progression criteria, 23.9% provided a sample size estimation and only 30.2% used qualitative methods. Conclusions Pilot studies are increasingly being used to inform HIV research. However, the titles and objectives are not always consistent with piloting. The design and reporting of pilot studies in HIV could be improved.
format	article
author	Hussein Ali El-Khechen Mohammed Inam Ullah Khan Selvin Leenus Oluwatobi Olaiya Zoha Durrani Zaryan Masood Alvin Leenus Shakib Akhter Lawrence Mbuagbaw
author_facet	Hussein Ali El-Khechen Mohammed Inam Ullah Khan Selvin Leenus Oluwatobi Olaiya Zoha Durrani Zaryan Masood Alvin Leenus Shakib Akhter Lawrence Mbuagbaw
author_sort	Hussein Ali El-Khechen
title	Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study
title_short	Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study
title_full	Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study
title_fullStr	Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study
title_full_unstemmed	Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study
title_sort	design, analysis, and reporting of pilot studies in hiv: a systematic review and methodological study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4f3742647e244e7291bf3caeb40843dd
work_keys_str_mv	AT husseinalielkhechen designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT mohammedinamullahkhan designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT selvinleenus designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT oluwatobiolaiya designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT zohadurrani designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT zaryanmasood designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT alvinleenus designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT shakibakhter designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy AT lawrencembuagbaw designanalysisandreportingofpilotstudiesinhivasystematicreviewandmethodologicalstudy
_version_	1718372190463721472

Design, analysis, and reporting of pilot studies in HIV: a systematic review and methodological study

Ejemplares similares