Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

The hydroxylase EgIN2 contributes to triple negative breast cancers. Here, using an enzyme-substrate trapping strategy, the authors identify ASDL as a bona fide substrate of EgIN2 promoting aggressive properties of TNBC via the activation of cMYC signaling.

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Autores principales:	Giada Zurlo, Xijuan Liu, Mamoru Takada, Cheng Fan, Jeremy M. Simon, Travis S. Ptacek, Javier Rodriguez, Alex von Kriegsheim, Juan Liu, Jason W. Locasale, Adam Robinson, Jing Zhang, Jessica M. Holler, Baek Kim, Marie Zikánová, Jörgen Bierau, Ling Xie, Xian Chen, Mingjie Li, Charles M. Perou, Qing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f3b6b5738bf4496a2ce34dde8289124
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spelling	oai:doaj.org-article:4f3b6b5738bf4496a2ce34dde82891242021-12-02T17:01:52ZProlyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer10.1038/s41467-019-13168-42041-1723https://doaj.org/article/4f3b6b5738bf4496a2ce34dde82891242019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13168-4https://doaj.org/toc/2041-1723The hydroxylase EgIN2 contributes to triple negative breast cancers. Here, using an enzyme-substrate trapping strategy, the authors identify ASDL as a bona fide substrate of EgIN2 promoting aggressive properties of TNBC via the activation of cMYC signaling.Giada ZurloXijuan LiuMamoru TakadaCheng FanJeremy M. SimonTravis S. PtacekJavier RodriguezAlex von KriegsheimJuan LiuJason W. LocasaleAdam RobinsonJing ZhangJessica M. HollerBaek KimMarie ZikánováJörgen BierauLing XieXian ChenMingjie LiCharles M. PerouQing ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giada Zurlo Xijuan Liu Mamoru Takada Cheng Fan Jeremy M. Simon Travis S. Ptacek Javier Rodriguez Alex von Kriegsheim Juan Liu Jason W. Locasale Adam Robinson Jing Zhang Jessica M. Holler Baek Kim Marie Zikánová Jörgen Bierau Ling Xie Xian Chen Mingjie Li Charles M. Perou Qing Zhang Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
description	The hydroxylase EgIN2 contributes to triple negative breast cancers. Here, using an enzyme-substrate trapping strategy, the authors identify ASDL as a bona fide substrate of EgIN2 promoting aggressive properties of TNBC via the activation of cMYC signaling.
format	article
author	Giada Zurlo Xijuan Liu Mamoru Takada Cheng Fan Jeremy M. Simon Travis S. Ptacek Javier Rodriguez Alex von Kriegsheim Juan Liu Jason W. Locasale Adam Robinson Jing Zhang Jessica M. Holler Baek Kim Marie Zikánová Jörgen Bierau Ling Xie Xian Chen Mingjie Li Charles M. Perou Qing Zhang
author_facet	Giada Zurlo Xijuan Liu Mamoru Takada Cheng Fan Jeremy M. Simon Travis S. Ptacek Javier Rodriguez Alex von Kriegsheim Juan Liu Jason W. Locasale Adam Robinson Jing Zhang Jessica M. Holler Baek Kim Marie Zikánová Jörgen Bierau Ling Xie Xian Chen Mingjie Li Charles M. Perou Qing Zhang
author_sort	Giada Zurlo
title	Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
title_short	Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
title_full	Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
title_fullStr	Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
title_full_unstemmed	Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
title_sort	prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4f3b6b5738bf4496a2ce34dde8289124
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Prolyl hydroxylase substrate adenylosuccinate lyase is an oncogenic driver in triple negative breast cancer

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