Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.

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Autores principales:	Noura Alzahofi, Tobias Welz, Christopher L. Robinson, Emma L. Page, Deborah A. Briggs, Amy K. Stainthorp, James Reekes, David A. Elbe, Felix Straub, Wouter W. Kallemeijn, Edward W. Tate, Philip S. Goff, Elena V. Sviderskaya, Marta Cantero, Lluis Montoliu, Francois Nedelec, Amanda K. Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N. Hume
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f3d5075c67d4d559d886e183af1f636
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spelling	oai:doaj.org-article:4f3d5075c67d4d559d886e183af1f6362021-12-02T16:08:14ZRab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins10.1038/s41467-020-17212-62041-1723https://doaj.org/article/4f3d5075c67d4d559d886e183af1f6362020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17212-6https://doaj.org/toc/2041-1723Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.Noura AlzahofiTobias WelzChristopher L. RobinsonEmma L. PageDeborah A. BriggsAmy K. StainthorpJames ReekesDavid A. ElbeFelix StraubWouter W. KallemeijnEdward W. TatePhilip S. GoffElena V. SviderskayaMarta CanteroLluis MontoliuFrancois NedelecAmanda K. MilesMaryse BaillyEugen KerkhoffAlistair N. HumeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noura Alzahofi Tobias Welz Christopher L. Robinson Emma L. Page Deborah A. Briggs Amy K. Stainthorp James Reekes David A. Elbe Felix Straub Wouter W. Kallemeijn Edward W. Tate Philip S. Goff Elena V. Sviderskaya Marta Cantero Lluis Montoliu Francois Nedelec Amanda K. Miles Maryse Bailly Eugen Kerkhoff Alistair N. Hume Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
description	Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.
format	article
author	Noura Alzahofi Tobias Welz Christopher L. Robinson Emma L. Page Deborah A. Briggs Amy K. Stainthorp James Reekes David A. Elbe Felix Straub Wouter W. Kallemeijn Edward W. Tate Philip S. Goff Elena V. Sviderskaya Marta Cantero Lluis Montoliu Francois Nedelec Amanda K. Miles Maryse Bailly Eugen Kerkhoff Alistair N. Hume
author_facet	Noura Alzahofi Tobias Welz Christopher L. Robinson Emma L. Page Deborah A. Briggs Amy K. Stainthorp James Reekes David A. Elbe Felix Straub Wouter W. Kallemeijn Edward W. Tate Philip S. Goff Elena V. Sviderskaya Marta Cantero Lluis Montoliu Francois Nedelec Amanda K. Miles Maryse Bailly Eugen Kerkhoff Alistair N. Hume
author_sort	Noura Alzahofi
title	Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
title_short	Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
title_full	Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
title_fullStr	Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
title_full_unstemmed	Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
title_sort	rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4f3d5075c67d4d559d886e183af1f636
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Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

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