Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins

Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.

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Detalles Bibliográficos
Autores principales: Noura Alzahofi, Tobias Welz, Christopher L. Robinson, Emma L. Page, Deborah A. Briggs, Amy K. Stainthorp, James Reekes, David A. Elbe, Felix Straub, Wouter W. Kallemeijn, Edward W. Tate, Philip S. Goff, Elena V. Sviderskaya, Marta Cantero, Lluis Montoliu, Francois Nedelec, Amanda K. Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N. Hume
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4f3d5075c67d4d559d886e183af1f636
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