Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes

Ana Catarina Pedrosa,1 Adriana Reis-Silva,2 João Pinheiro-Costa,1,3 João Beato,1 Paulo Freitas-da-Costa,1,3 Manuel S Falcão,1,2 Fernando Falcão-Reis,1,2 Ângela Carneiro1,2 1Department of Ophthalmology, Hospital de São João,...

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Autores principales:	Pedrosa AC, Reis-Silva A, Pinheiro-Costa J, Beato J, Freitas-da-Costa P, Falcão MS, Falcão-Reis F, Carneiro A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Age-related macular degeneration choroidal neovascularization vascular endothelial growth factor visual acuity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4f3e16e908ce445b96d51d8719abdbb8
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spelling	oai:doaj.org-article:4f3e16e908ce445b96d51d8719abdbb82021-12-02T00:06:42ZTreatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes1177-5483https://doaj.org/article/4f3e16e908ce445b96d51d8719abdbb82016-03-01T00:00:00Zhttps://www.dovepress.com/treatment-of-neovascular-age-related-macular-degeneration-with-anti-ve-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ana Catarina Pedrosa,1 Adriana Reis-Silva,2 João Pinheiro-Costa,1,3 João Beato,1 Paulo Freitas-da-Costa,1,3 Manuel S Falcão,1,2 Fernando Falcão-Reis,1,2 Ângela Carneiro1,2 1Department of Ophthalmology, Hospital de São João, 2Department of Sense Organs, 3Department of Anatomy, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To evaluate the 5-year results obtained in clinical practice in the treatment of neovascular age-related macular degeneration (nAMD) with anti-VEGF agents.  Materials and methods: We retrospectively analyzed all patients with nAMD who initiated anti-VEGF treatment before October 2009. We collected data regarding visual and anatomical outcomes.  Results: A total of 278 patients met the selection criteria. The mean number of intravitreal injections was 5.7 in the first year and 3.7 in the fifth year. A positive mean visual acuity variation of +3.7 Early Treatment Diabetic Retinopathy Study letters occurred in the first year, but no significant differences relative to baseline were observed thereafter. The majority of patients (71%) maintained stable visual acuity throughout follow-up. At 5 years, mean central macular thickness remained substantially inferior to baseline (-96.6 µm), and 56% of patients maintained dry retinas.  Conclusion: Anti-VEGF therapy leads to long-term visual stabilization in the great majority of patients. Keywords: age-related macular degeneration, choroidal neovascularization, vascular endothelial growth factor, visual acuityPedrosa ACReis-Silva APinheiro-Costa JBeato JFreitas-da-Costa PFalcão MSFalcão-Reis FCarneiro ADove Medical PressarticleAge-related macular degenerationchoroidal neovascularizationvascular endothelial growth factorvisual acuityOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 541-546 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Age-related macular degeneration choroidal neovascularization vascular endothelial growth factor visual acuity Ophthalmology RE1-994
spellingShingle	Age-related macular degeneration choroidal neovascularization vascular endothelial growth factor visual acuity Ophthalmology RE1-994 Pedrosa AC Reis-Silva A Pinheiro-Costa J Beato J Freitas-da-Costa P Falcão MS Falcão-Reis F Carneiro A Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
description	Ana Catarina Pedrosa,1 Adriana Reis-Silva,2 João Pinheiro-Costa,1,3 João Beato,1 Paulo Freitas-da-Costa,1,3 Manuel S Falcão,1,2 Fernando Falcão-Reis,1,2 Ângela Carneiro1,2 1Department of Ophthalmology, Hospital de São João, 2Department of Sense Organs, 3Department of Anatomy, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To evaluate the 5-year results obtained in clinical practice in the treatment of neovascular age-related macular degeneration (nAMD) with anti-VEGF agents.  Materials and methods: We retrospectively analyzed all patients with nAMD who initiated anti-VEGF treatment before October 2009. We collected data regarding visual and anatomical outcomes.  Results: A total of 278 patients met the selection criteria. The mean number of intravitreal injections was 5.7 in the first year and 3.7 in the fifth year. A positive mean visual acuity variation of +3.7 Early Treatment Diabetic Retinopathy Study letters occurred in the first year, but no significant differences relative to baseline were observed thereafter. The majority of patients (71%) maintained stable visual acuity throughout follow-up. At 5 years, mean central macular thickness remained substantially inferior to baseline (-96.6 µm), and 56% of patients maintained dry retinas.  Conclusion: Anti-VEGF therapy leads to long-term visual stabilization in the great majority of patients. Keywords: age-related macular degeneration, choroidal neovascularization, vascular endothelial growth factor, visual acuity
format	article
author	Pedrosa AC Reis-Silva A Pinheiro-Costa J Beato J Freitas-da-Costa P Falcão MS Falcão-Reis F Carneiro A
author_facet	Pedrosa AC Reis-Silva A Pinheiro-Costa J Beato J Freitas-da-Costa P Falcão MS Falcão-Reis F Carneiro A
author_sort	Pedrosa AC
title	Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
title_short	Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
title_full	Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
title_fullStr	Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
title_full_unstemmed	Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes
title_sort	treatment of neovascular age-related macular degeneration with anti-vegf agents: retrospective analysis of 5-year outcomes
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4f3e16e908ce445b96d51d8719abdbb8
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Treatment of neovascular age-related macular degeneration with anti-VEGF agents: retrospective analysis of 5-year outcomes

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