Molecular signatures of aneuploidy-driven adaptive evolution

Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the mechanisms that promote tolerance of aneuploidy.

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Autores principales: Alaattin Kaya, Marco Mariotti, Alexander Tyshkovskiy, Xuming Zhou, Michelle L. Hulke, Siming Ma, Maxim V. Gerashchenko, Amnon Koren, Vadim N. Gladyshev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4f3f99b49ed24244a72ed99940240c13
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Sumario:Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the mechanisms that promote tolerance of aneuploidy.