Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas

Abstract The ability to generate humor gives rise to positive emotions and thus facilitate the successful resolution of adversity. Although there is consensus that inhibitory processes might be related to broaden the way of thinking, the neural underpinnings of these mechanisms are largely unknown....

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Autores principales:	Florian Bitsch, Philipp Berger, Andreas Fink, Arne Nagels, Benjamin Straube, Irina Falkenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f410506c2a54025b3048154c2c6ca75
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spelling	oai:doaj.org-article:4f410506c2a54025b3048154c2c6ca752021-12-02T15:45:32ZAntagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas10.1038/s41598-021-89843-82045-2322https://doaj.org/article/4f410506c2a54025b3048154c2c6ca752021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89843-8https://doaj.org/toc/2045-2322Abstract The ability to generate humor gives rise to positive emotions and thus facilitate the successful resolution of adversity. Although there is consensus that inhibitory processes might be related to broaden the way of thinking, the neural underpinnings of these mechanisms are largely unknown. Here, we use functional Magnetic Resonance Imaging, a humorous alternative uses task and a stroop task, to investigate the brain mechanisms underlying the emergence of humorous ideas in 24 subjects. Neuroimaging results indicate that greater cognitive control abilities are associated with increased activation in the amygdala, the hippocampus and the superior and medial frontal gyrus during the generation of humorous ideas. Examining the neural mechanisms more closely shows that the hypoactivation of frontal brain regions is associated with an hyperactivation in the amygdala and vice versa. This antagonistic connectivity is concurrently linked with an increased number of humorous ideas and enhanced amygdala responses during the task. Our data therefore suggests that a neural antagonism previously related to the emergence and regulation of negative affective responses, is linked with the generation of emotionally positive ideas and may represent an important neural pathway supporting mental health.Florian BitschPhilipp BergerAndreas FinkArne NagelsBenjamin StraubeIrina FalkenbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Florian Bitsch Philipp Berger Andreas Fink Arne Nagels Benjamin Straube Irina Falkenberg Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
description	Abstract The ability to generate humor gives rise to positive emotions and thus facilitate the successful resolution of adversity. Although there is consensus that inhibitory processes might be related to broaden the way of thinking, the neural underpinnings of these mechanisms are largely unknown. Here, we use functional Magnetic Resonance Imaging, a humorous alternative uses task and a stroop task, to investigate the brain mechanisms underlying the emergence of humorous ideas in 24 subjects. Neuroimaging results indicate that greater cognitive control abilities are associated with increased activation in the amygdala, the hippocampus and the superior and medial frontal gyrus during the generation of humorous ideas. Examining the neural mechanisms more closely shows that the hypoactivation of frontal brain regions is associated with an hyperactivation in the amygdala and vice versa. This antagonistic connectivity is concurrently linked with an increased number of humorous ideas and enhanced amygdala responses during the task. Our data therefore suggests that a neural antagonism previously related to the emergence and regulation of negative affective responses, is linked with the generation of emotionally positive ideas and may represent an important neural pathway supporting mental health.
format	article
author	Florian Bitsch Philipp Berger Andreas Fink Arne Nagels Benjamin Straube Irina Falkenberg
author_facet	Florian Bitsch Philipp Berger Andreas Fink Arne Nagels Benjamin Straube Irina Falkenberg
author_sort	Florian Bitsch
title	Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
title_short	Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
title_full	Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
title_fullStr	Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
title_full_unstemmed	Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
title_sort	antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4f410506c2a54025b3048154c2c6ca75
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Antagonism between brain regions relevant for cognitive control and emotional memory facilitates the generation of humorous ideas

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