Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)

Cancer is the second cause of death worldwide. Among cancers, hepatocellular carcinoma is one of the most prevalent. Evidence indicates that the daily consumption of fruits and vegetables can prevent the onset of various cancers due to the presence of bioactive compounds. Sweet cherries are known fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana C. Gonçalves, José D. Flores-Félix, Ana R. Costa, Amílcar Falcão, Gilberto Alves, Luís R. Silva
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antioxidant effects cytotoxicity molecular docking HepG2 cells sweet cherry phenolics Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/4f434326a9b0474591ec6a8d92d6fce0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f434326a9b0474591ec6a8d92d6fce0
record_format	dspace
spelling	oai:doaj.org-article:4f434326a9b0474591ec6a8d92d6fce02021-11-25T17:33:34ZHepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)10.3390/foods101126232304-8158https://doaj.org/article/4f434326a9b0474591ec6a8d92d6fce02021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2623https://doaj.org/toc/2304-8158Cancer is the second cause of death worldwide. Among cancers, hepatocellular carcinoma is one of the most prevalent. Evidence indicates that the daily consumption of fruits and vegetables can prevent the onset of various cancers due to the presence of bioactive compounds. Sweet cherries are known for their richness in phenolics, including anthocyanins, which are the major constituents, and presumably, the key contributors to their biological activity. Therefore, the present study aimed to evaluate the effects of three different cherry fractions on human hepatocellular carcinoma (HepG2) cells viability and effectiveness to improve the redox status of these cells under oxidative damage induced by nitric oxide radicals and hydrogen peroxide. Phenolic characterization of fractions was performed by Fourier transform infrared spectroscopy. The obtained results indicated that enriched phenolic fractions of sweet cherries (cv. Saco, can impair cell viability and suppress cells growth after 72 h of exposure, promoting necrosis at the highest tested concentrations (>50 µg/mL). Additionally, fractions also showed the capacity to protect these cells against oxidative injury by capturing radicals before they can attack cells’ membrane and by modulating reactive oxygen and nitrogen species generation, as demonstrated by bioinformatic tools.Ana C. GonçalvesJosé D. Flores-FélixAna R. CostaAmílcar FalcãoGilberto AlvesLuís R. SilvaMDPI AGarticleantioxidant effectscytotoxicitymolecular dockingHepG2 cellssweet cherry phenolicsChemical technologyTP1-1185ENFoods, Vol 10, Iss 2623, p 2623 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant effects cytotoxicity molecular docking HepG2 cells sweet cherry phenolics Chemical technology TP1-1185
spellingShingle	antioxidant effects cytotoxicity molecular docking HepG2 cells sweet cherry phenolics Chemical technology TP1-1185 Ana C. Gonçalves José D. Flores-Félix Ana R. Costa Amílcar Falcão Gilberto Alves Luís R. Silva Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
description	Cancer is the second cause of death worldwide. Among cancers, hepatocellular carcinoma is one of the most prevalent. Evidence indicates that the daily consumption of fruits and vegetables can prevent the onset of various cancers due to the presence of bioactive compounds. Sweet cherries are known for their richness in phenolics, including anthocyanins, which are the major constituents, and presumably, the key contributors to their biological activity. Therefore, the present study aimed to evaluate the effects of three different cherry fractions on human hepatocellular carcinoma (HepG2) cells viability and effectiveness to improve the redox status of these cells under oxidative damage induced by nitric oxide radicals and hydrogen peroxide. Phenolic characterization of fractions was performed by Fourier transform infrared spectroscopy. The obtained results indicated that enriched phenolic fractions of sweet cherries (cv. Saco, can impair cell viability and suppress cells growth after 72 h of exposure, promoting necrosis at the highest tested concentrations (>50 µg/mL). Additionally, fractions also showed the capacity to protect these cells against oxidative injury by capturing radicals before they can attack cells’ membrane and by modulating reactive oxygen and nitrogen species generation, as demonstrated by bioinformatic tools.
format	article
author	Ana C. Gonçalves José D. Flores-Félix Ana R. Costa Amílcar Falcão Gilberto Alves Luís R. Silva
author_facet	Ana C. Gonçalves José D. Flores-Félix Ana R. Costa Amílcar Falcão Gilberto Alves Luís R. Silva
author_sort	Ana C. Gonçalves
title	Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
title_short	Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
title_full	Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
title_fullStr	Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
title_full_unstemmed	Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)
title_sort	hepatoprotective effects of sweet cherry extracts (cv. saco)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f434326a9b0474591ec6a8d92d6fce0
work_keys_str_mv	AT anacgoncalves hepatoprotectiveeffectsofsweetcherryextractscvsaco AT josedfloresfelix hepatoprotectiveeffectsofsweetcherryextractscvsaco AT anarcosta hepatoprotectiveeffectsofsweetcherryextractscvsaco AT amilcarfalcao hepatoprotectiveeffectsofsweetcherryextractscvsaco AT gilbertoalves hepatoprotectiveeffectsofsweetcherryextractscvsaco AT luisrsilva hepatoprotectiveeffectsofsweetcherryextractscvsaco
_version_	1718412222141562880

Hepatoprotective Effects of Sweet Cherry Extracts (cv. Saco)

Ejemplares similares