CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS

Abstract. The purpose of present work was to study the peculiarities of cytokine production in patients with malignant tumors, as exemplified by lymphoma and malignant melanoma. Sixty-five patients with malignancies (16 to 74 years old) have been surveyed. Contents of IL-1β, IL-4, TNFα and lactoferr...

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Autores principales:	T. I. Dolgikh, E. J. Bychkova, R. H. Galyulin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines lactoferrin lymphoma melanoma il-1β il-4 tnfα Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4f465e3c0ea44c868d72aef005abc222
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spelling	oai:doaj.org-article:4f465e3c0ea44c868d72aef005abc2222021-11-18T08:03:37ZCONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS1563-06252313-741X10.15789/1563-0625-2008-1-67-70https://doaj.org/article/4f465e3c0ea44c868d72aef005abc2222014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/82https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The purpose of present work was to study the peculiarities of cytokine production in patients with malignant tumors, as exemplified by lymphoma and malignant melanoma. Sixty-five patients with malignancies (16 to 74 years old) have been surveyed. Contents of IL-1β, IL-4, TNFα and lactoferrin were studied in blood serum using enzyme immunoassay technique. The results of study have shown that the patients with melanoma have a significant reduction in IL-1-β and TNFα in blood serum, thus being suggestive for development of deficient immune response. In malignant lymphoma, the patients did also exhibit subnormal values of TNFα and IL-1β (below a threshold level of 5 pg/ml), thus supposing some deficiency in proinflammatory cytokine secretion. An interrelation was shown between the contents of lactoferrin and proinflammatory cytokines. After radical treatment of melanoma, like as in lymphoma patients free of В-symptoms, the lactoferrin contents were within normal limits, whereas in the patients with generalization of malignancy, and in lymphoma patients with В-symptoms, a trend to its increase has been established. Determination of the mentioned parameters in patients with lymphoma and malignant melanoma would provide useful diagnostic and predictive criteria in these clinical conditions.T. I. DolgikhE. J. BychkovaR. H. GalyulinSPb RAACIarticlecytokineslactoferrinlymphomamelanomail-1βil-4tnfαImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 1, Pp 67-70 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines lactoferrin lymphoma melanoma il-1β il-4 tnfα Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines lactoferrin lymphoma melanoma il-1β il-4 tnfα Immunologic diseases. Allergy RC581-607 T. I. Dolgikh E. J. Bychkova R. H. Galyulin CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
description	Abstract. The purpose of present work was to study the peculiarities of cytokine production in patients with malignant tumors, as exemplified by lymphoma and malignant melanoma. Sixty-five patients with malignancies (16 to 74 years old) have been surveyed. Contents of IL-1β, IL-4, TNFα and lactoferrin were studied in blood serum using enzyme immunoassay technique. The results of study have shown that the patients with melanoma have a significant reduction in IL-1-β and TNFα in blood serum, thus being suggestive for development of deficient immune response. In malignant lymphoma, the patients did also exhibit subnormal values of TNFα and IL-1β (below a threshold level of 5 pg/ml), thus supposing some deficiency in proinflammatory cytokine secretion. An interrelation was shown between the contents of lactoferrin and proinflammatory cytokines. After radical treatment of melanoma, like as in lymphoma patients free of В-symptoms, the lactoferrin contents were within normal limits, whereas in the patients with generalization of malignancy, and in lymphoma patients with В-symptoms, a trend to its increase has been established. Determination of the mentioned parameters in patients with lymphoma and malignant melanoma would provide useful diagnostic and predictive criteria in these clinical conditions.
format	article
author	T. I. Dolgikh E. J. Bychkova R. H. Galyulin
author_facet	T. I. Dolgikh E. J. Bychkova R. H. Galyulin
author_sort	T. I. Dolgikh
title	CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
title_short	CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
title_full	CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
title_fullStr	CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
title_full_unstemmed	CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS
title_sort	contents of cytokines and lactoferrin in oncological patients
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/4f465e3c0ea44c868d72aef005abc222
work_keys_str_mv	AT tidolgikh contentsofcytokinesandlactoferrininoncologicalpatients AT ejbychkova contentsofcytokinesandlactoferrininoncologicalpatients AT rhgalyulin contentsofcytokinesandlactoferrininoncologicalpatients
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CONTENTS OF CYTOKINES AND LACTOFERRIN IN ONCOLOGICAL PATIENTS

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