Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults
Abstract We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the cor...
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Nature Portfolio
2020
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oai:doaj.org-article:4f486b4516194bc6ad4d62d1c75efe742021-12-02T16:31:46ZAssociations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults10.1038/s41598-020-67516-22045-2322https://doaj.org/article/4f486b4516194bc6ad4d62d1c75efe742020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67516-2https://doaj.org/toc/2045-2322Abstract We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2, FCN3 and MBL2). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (p < 0.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (p < 0.000001, p < 0.000001 and p = 0.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and/or fungaemia) (p = 0.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (> 7 days) fever (p = 0.026). Genotyping indicated an association of G/G homozygosity (corresponding to FCN1 gene − 542 G > A polymorphism) with malignancy [p = 0.004, OR = 2.95, 95% CI (1.41–6.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated.Anna SokołowskaAnna S. ŚwierzkoGabriela GajekAleksandra GołosMateusz MichalskiMateusz NowickiAgnieszka Szala-PoździejAnna Wolska-WasherOlga BrzezińskaAgnieszka WierzbowskaKrzysztof JamroziakMarek L. KowalskiSteffen ThielMisao MatsushitaJens C. JenseniusMaciej CedzyńskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) |
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Medicine R Science Q Anna Sokołowska Anna S. Świerzko Gabriela Gajek Aleksandra Gołos Mateusz Michalski Mateusz Nowicki Agnieszka Szala-Poździej Anna Wolska-Washer Olga Brzezińska Agnieszka Wierzbowska Krzysztof Jamroziak Marek L. Kowalski Steffen Thiel Misao Matsushita Jens C. Jensenius Maciej Cedzyński Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| description |
Abstract We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2, FCN3 and MBL2). The control group (C) consisted of 267 healthy unrelated individuals. Median level of ficolin-1 in patients was lower (p < 0.000001) while median levels of ficolin-2, ficolin-3 and MBL were higher (p < 0.000001, p < 0.000001 and p = 0.0016, respectively) compared with controls. These findings were generally associated with AML itself, however the highest MBL levels predicted higher risk of severe hospital infections (accompanied with bacteremia and/or fungaemia) (p = 0.012) while the lowest ficolin-1 concentrations tended to be associated with prolonged (> 7 days) fever (p = 0.026). Genotyping indicated an association of G/G homozygosity (corresponding to FCN1 gene − 542 G > A polymorphism) with malignancy [p = 0.004, OR = 2.95, 95% CI (1.41–6.16)]. Based on ROC analysis, ficolin-1, -2 and -3 may be considered candidate supplementary biomarkers of AML. Their high potential to differentiate between patients from non-malignant controls but also from persons suffering from other haematological cancers (multiple myeloma and lymphoma) was demonstrated. |
| format |
article |
| author |
Anna Sokołowska Anna S. Świerzko Gabriela Gajek Aleksandra Gołos Mateusz Michalski Mateusz Nowicki Agnieszka Szala-Poździej Anna Wolska-Washer Olga Brzezińska Agnieszka Wierzbowska Krzysztof Jamroziak Marek L. Kowalski Steffen Thiel Misao Matsushita Jens C. Jensenius Maciej Cedzyński |
| author_facet |
Anna Sokołowska Anna S. Świerzko Gabriela Gajek Aleksandra Gołos Mateusz Michalski Mateusz Nowicki Agnieszka Szala-Poździej Anna Wolska-Washer Olga Brzezińska Agnieszka Wierzbowska Krzysztof Jamroziak Marek L. Kowalski Steffen Thiel Misao Matsushita Jens C. Jensenius Maciej Cedzyński |
| author_sort |
Anna Sokołowska |
| title |
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_short |
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_full |
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_fullStr |
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_full_unstemmed |
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| title_sort |
associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4f486b4516194bc6ad4d62d1c75efe74 |
| work_keys_str_mv |
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