Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease

Hypoxemia and obstructive sleep apnea (OSA) have been recognized as a threat to life. Nonetheless, information regarding the association between pre-dialytic pulse oximeter saturation (SpO2) level, OSA and mortality risks remains mysterious in patients with maintenance hemodialysis (MHD). Bioclinica...

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Autores principales:	Hsiao-Wei Lu, Pin-Hung Kuo, Cheuk-Sing Choy, Chih-Yu Hsieh, Jia-Feng Chang, Mai-Szu Wu, Jing-Quan Zheng, Jian-Chiun Liou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pulse oximetry obstructive sleep apnea cardiovascular mortality LED wearable device hemodialysis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/4f4ba22a47f44d2eb9f7c3df3f359cff
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spelling	oai:doaj.org-article:4f4ba22a47f44d2eb9f7c3df3f359cff2021-11-25T16:34:57ZPre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease10.3390/app1122106742076-3417https://doaj.org/article/4f4ba22a47f44d2eb9f7c3df3f359cff2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10674https://doaj.org/toc/2076-3417Hypoxemia and obstructive sleep apnea (OSA) have been recognized as a threat to life. Nonetheless, information regarding the association between pre-dialytic pulse oximeter saturation (SpO2) level, OSA and mortality risks remains mysterious in patients with maintenance hemodialysis (MHD). Bioclinical characteristics and laboratory features were recorded at baseline. Pre-dialytic SpO2 was detected using a novel microchip LED oximetry, and the Epworth Sleepiness Scale (ESS) score greater than 10 indicated OSA. Non-adjusted and adjusted hazard ratios (aHRs) of all-cause and cardiovascular (CV) mortality were analyzed for pre-dialytic SpO2, OSA and potential risk factors. During 2152.8 patient-months of follow-up, SpO2 was associated with incremental risks of all-cause and CV death (HR: 0.90 (95% CI: 0.82–0.98) and 0.88 (95% CI: 0.80–0.98), respectively). The association between OSA and CV mortality was significant (HR: 3.19 (95% CI: 1.19–9.38). In the multivariate regression analysis, pre-dialytic SpO2 still had an increase in all-cause and CV death risk (HR: 0.88 (95% CI: 0.79–0.98), 0.82 (95% CI: 0.71–0.96), respectively). Considering the high prevalence of silent hypoxia in the post COVID-19 era, a lower pre-dialytic SpO2 level and severe OSA warn clinicians to assess potential CV risks. In light of clinical accessibility, the microchip LED oximetry could be developed as a wearable device within smartphone technologies and used as a routine screen tool for patient safety in the medical system.Hsiao-Wei LuPin-Hung KuoCheuk-Sing ChoyChih-Yu HsiehJia-Feng ChangMai-Szu WuJing-Quan ZhengJian-Chiun LiouMDPI AGarticlepulse oximetryobstructive sleep apneacardiovascular mortalityLEDwearable devicehemodialysisTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10674, p 10674 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulse oximetry obstructive sleep apnea cardiovascular mortality LED wearable device hemodialysis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	pulse oximetry obstructive sleep apnea cardiovascular mortality LED wearable device hemodialysis Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Hsiao-Wei Lu Pin-Hung Kuo Cheuk-Sing Choy Chih-Yu Hsieh Jia-Feng Chang Mai-Szu Wu Jing-Quan Zheng Jian-Chiun Liou Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease
description	Hypoxemia and obstructive sleep apnea (OSA) have been recognized as a threat to life. Nonetheless, information regarding the association between pre-dialytic pulse oximeter saturation (SpO2) level, OSA and mortality risks remains mysterious in patients with maintenance hemodialysis (MHD). Bioclinical characteristics and laboratory features were recorded at baseline. Pre-dialytic SpO2 was detected using a novel microchip LED oximetry, and the Epworth Sleepiness Scale (ESS) score greater than 10 indicated OSA. Non-adjusted and adjusted hazard ratios (aHRs) of all-cause and cardiovascular (CV) mortality were analyzed for pre-dialytic SpO2, OSA and potential risk factors. During 2152.8 patient-months of follow-up, SpO2 was associated with incremental risks of all-cause and CV death (HR: 0.90 (95% CI: 0.82–0.98) and 0.88 (95% CI: 0.80–0.98), respectively). The association between OSA and CV mortality was significant (HR: 3.19 (95% CI: 1.19–9.38). In the multivariate regression analysis, pre-dialytic SpO2 still had an increase in all-cause and CV death risk (HR: 0.88 (95% CI: 0.79–0.98), 0.82 (95% CI: 0.71–0.96), respectively). Considering the high prevalence of silent hypoxia in the post COVID-19 era, a lower pre-dialytic SpO2 level and severe OSA warn clinicians to assess potential CV risks. In light of clinical accessibility, the microchip LED oximetry could be developed as a wearable device within smartphone technologies and used as a routine screen tool for patient safety in the medical system.
format	article
author	Hsiao-Wei Lu Pin-Hung Kuo Cheuk-Sing Choy Chih-Yu Hsieh Jia-Feng Chang Mai-Szu Wu Jing-Quan Zheng Jian-Chiun Liou
author_facet	Hsiao-Wei Lu Pin-Hung Kuo Cheuk-Sing Choy Chih-Yu Hsieh Jia-Feng Chang Mai-Szu Wu Jing-Quan Zheng Jian-Chiun Liou
author_sort	Hsiao-Wei Lu
title	Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease
title_short	Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease
title_full	Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease
title_fullStr	Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease
title_full_unstemmed	Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease
title_sort	pre-dialytic spo2 measured with a wearable device as a predictor of mortality in patients with osa and chronic kidney disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f4ba22a47f44d2eb9f7c3df3f359cff
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Pre-Dialytic SpO2 Measured with a Wearable Device as a Predictor of Mortality in Patients with OSA and Chronic Kidney Disease

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