Long-term hepatitis B infection in a scalable hepatic co-culture system

The lack of models that mimic hepatitis B virus (HBV) infection in a physiologically relevant context has hampered drug development. Here, Winer et al. establish a self-assembling, primary hepatocyte co-culture system that can be infected with patient-derived HBV without further modifications.

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Autores principales:	Benjamin Y. Winer, Tiffany S. Huang, Eitan Pludwinski, Brigitte Heller, Felix Wojcik, Gabriel E. Lipkowitz, Amit Parekh, Cheul Cho, Anil Shrirao, Tom W. Muir, Eric Novik, Alexander Ploss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f4d70c28e204829955bdea52e1122f1
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spelling	oai:doaj.org-article:4f4d70c28e204829955bdea52e1122f12021-12-02T13:57:54ZLong-term hepatitis B infection in a scalable hepatic co-culture system10.1038/s41467-017-00200-82041-1723https://doaj.org/article/4f4d70c28e204829955bdea52e1122f12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00200-8https://doaj.org/toc/2041-1723The lack of models that mimic hepatitis B virus (HBV) infection in a physiologically relevant context has hampered drug development. Here, Winer et al. establish a self-assembling, primary hepatocyte co-culture system that can be infected with patient-derived HBV without further modifications.Benjamin Y. WinerTiffany S. HuangEitan PludwinskiBrigitte HellerFelix WojcikGabriel E. LipkowitzAmit ParekhCheul ChoAnil ShriraoTom W. MuirEric NovikAlexander PlossNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Y. Winer Tiffany S. Huang Eitan Pludwinski Brigitte Heller Felix Wojcik Gabriel E. Lipkowitz Amit Parekh Cheul Cho Anil Shrirao Tom W. Muir Eric Novik Alexander Ploss Long-term hepatitis B infection in a scalable hepatic co-culture system
description	The lack of models that mimic hepatitis B virus (HBV) infection in a physiologically relevant context has hampered drug development. Here, Winer et al. establish a self-assembling, primary hepatocyte co-culture system that can be infected with patient-derived HBV without further modifications.
format	article
author	Benjamin Y. Winer Tiffany S. Huang Eitan Pludwinski Brigitte Heller Felix Wojcik Gabriel E. Lipkowitz Amit Parekh Cheul Cho Anil Shrirao Tom W. Muir Eric Novik Alexander Ploss
author_facet	Benjamin Y. Winer Tiffany S. Huang Eitan Pludwinski Brigitte Heller Felix Wojcik Gabriel E. Lipkowitz Amit Parekh Cheul Cho Anil Shrirao Tom W. Muir Eric Novik Alexander Ploss
author_sort	Benjamin Y. Winer
title	Long-term hepatitis B infection in a scalable hepatic co-culture system
title_short	Long-term hepatitis B infection in a scalable hepatic co-culture system
title_full	Long-term hepatitis B infection in a scalable hepatic co-culture system
title_fullStr	Long-term hepatitis B infection in a scalable hepatic co-culture system
title_full_unstemmed	Long-term hepatitis B infection in a scalable hepatic co-culture system
title_sort	long-term hepatitis b infection in a scalable hepatic co-culture system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4f4d70c28e204829955bdea52e1122f1
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Long-term hepatitis B infection in a scalable hepatic co-culture system

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