A database of breast oncogenic specific siRNAs

Abstract Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel...

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Autores principales:	Atul Tyagi, Manoj Semwal, Ashok Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f525951f5ab46be85cd562135e292d4
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spelling	oai:doaj.org-article:4f525951f5ab46be85cd562135e292d42021-12-02T16:06:36ZA database of breast oncogenic specific siRNAs10.1038/s41598-017-08948-12045-2322https://doaj.org/article/4f525951f5ab46be85cd562135e292d42017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08948-1https://doaj.org/toc/2045-2322Abstract Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel therapeutic strategies for breast cancer. Therefore, identification of such molecules having high oncogene specificity is the need of the hour. Here, we have developed a database named as Breast Oncogenic Specific siRNAs (BOSS, http://bioinformatics.cimap.res.in/sharma/boss/ ) on the basis of the current research status on siRNA-mediated repression of oncogenes in different breast cancer cell lines. BOSS is a resource of experimentally validated breast oncogenic siRNAs, collected from research articles and patents published yet. The present database contains information on 865 breast oncogenic siRNA entries. Each entry provides comprehensive information of an siRNA that includes its name, sequence, target gene, type of cells, and inhibition value, etc. Additionally, some useful tools like siRNAMAP and BOSS BLAST were also developed and linked with the database. siRNAMAP can be used for the selection of best siRNA against a target gene while BOSS BLAST tool helps to locate the siRNA sequences in deferent oncogenes.Atul TyagiManoj SemwalAshok SharmaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atul Tyagi Manoj Semwal Ashok Sharma A database of breast oncogenic specific siRNAs
description	Abstract Breast cancer is a serious problem causing the death of women across the world. At present, one of the major challenges is to design drugs to target breast cancer specific gene(s). RNA interference (RNAi) is an important technique for targeted gene silencing that may lead to promising novel therapeutic strategies for breast cancer. Therefore, identification of such molecules having high oncogene specificity is the need of the hour. Here, we have developed a database named as Breast Oncogenic Specific siRNAs (BOSS, http://bioinformatics.cimap.res.in/sharma/boss/ ) on the basis of the current research status on siRNA-mediated repression of oncogenes in different breast cancer cell lines. BOSS is a resource of experimentally validated breast oncogenic siRNAs, collected from research articles and patents published yet. The present database contains information on 865 breast oncogenic siRNA entries. Each entry provides comprehensive information of an siRNA that includes its name, sequence, target gene, type of cells, and inhibition value, etc. Additionally, some useful tools like siRNAMAP and BOSS BLAST were also developed and linked with the database. siRNAMAP can be used for the selection of best siRNA against a target gene while BOSS BLAST tool helps to locate the siRNA sequences in deferent oncogenes.
format	article
author	Atul Tyagi Manoj Semwal Ashok Sharma
author_facet	Atul Tyagi Manoj Semwal Ashok Sharma
author_sort	Atul Tyagi
title	A database of breast oncogenic specific siRNAs
title_short	A database of breast oncogenic specific siRNAs
title_full	A database of breast oncogenic specific siRNAs
title_fullStr	A database of breast oncogenic specific siRNAs
title_full_unstemmed	A database of breast oncogenic specific siRNAs
title_sort	database of breast oncogenic specific sirnas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4f525951f5ab46be85cd562135e292d4
work_keys_str_mv	AT atultyagi adatabaseofbreastoncogenicspecificsirnas AT manojsemwal adatabaseofbreastoncogenicspecificsirnas AT ashoksharma adatabaseofbreastoncogenicspecificsirnas AT atultyagi databaseofbreastoncogenicspecificsirnas AT manojsemwal databaseofbreastoncogenicspecificsirnas AT ashoksharma databaseofbreastoncogenicspecificsirnas
_version_	1718384959677267968

A database of breast oncogenic specific siRNAs

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