Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity between the estrogen receptor and the beta-tubulin...

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Auteurs principaux:	Yu-Chen Lo, Olga Cormier, Tianyun Liu, Kendall W. Nettles, John A. Katzenellenbogen, Tim Stearns, Russ B. Altman
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/4f53cf47f3b541639d8068e57a147f70
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spelling	oai:doaj.org-article:4f53cf47f3b541639d8068e57a147f702021-12-02T17:01:53ZPocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site10.1038/s41467-019-08965-w2041-1723https://doaj.org/article/4f53cf47f3b541639d8068e57a147f702019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08965-whttps://doaj.org/toc/2041-1723Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity between the estrogen receptor and the beta-tubulin taxane binding pocket.Yu-Chen LoOlga CormierTianyun LiuKendall W. NettlesJohn A. KatzenellenbogenTim StearnsRuss B. AltmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Chen Lo Olga Cormier Tianyun Liu Kendall W. Nettles John A. Katzenellenbogen Tim Stearns Russ B. Altman Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
description	Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity between the estrogen receptor and the beta-tubulin taxane binding pocket.
format	article
author	Yu-Chen Lo Olga Cormier Tianyun Liu Kendall W. Nettles John A. Katzenellenbogen Tim Stearns Russ B. Altman
author_facet	Yu-Chen Lo Olga Cormier Tianyun Liu Kendall W. Nettles John A. Katzenellenbogen Tim Stearns Russ B. Altman
author_sort	Yu-Chen Lo
title	Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
title_short	Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
title_full	Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
title_fullStr	Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
title_full_unstemmed	Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
title_sort	pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4f53cf47f3b541639d8068e57a147f70
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Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

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