MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stel...

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Autores principales:	Jeongeun Hyun, Sihyung Wang, Jieun Kim, Kummara Madhusudana Rao, Soo Yong Park, Ildoo Chung, Chang-Sik Ha, Sang-Woo Kim, Yang H. Yun, Youngmi Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f54381c8f96469a82e5f4d6d35090c7
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spelling	oai:doaj.org-article:4f54381c8f96469a82e5f4d6d35090c72021-12-02T15:35:20ZMicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression10.1038/ncomms109932041-1723https://doaj.org/article/4f54381c8f96469a82e5f4d6d35090c72016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10993https://doaj.org/toc/2041-1723Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stellate cells.Jeongeun HyunSihyung WangJieun KimKummara Madhusudana RaoSoo Yong ParkIldoo ChungChang-Sik HaSang-Woo KimYang H. YunYoungmi JungNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeongeun Hyun Sihyung Wang Jieun Kim Kummara Madhusudana Rao Soo Yong Park Ildoo Chung Chang-Sik Ha Sang-Woo Kim Yang H. Yun Youngmi Jung MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
description	Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stellate cells.
format	article
author	Jeongeun Hyun Sihyung Wang Jieun Kim Kummara Madhusudana Rao Soo Yong Park Ildoo Chung Chang-Sik Ha Sang-Woo Kim Yang H. Yun Youngmi Jung
author_facet	Jeongeun Hyun Sihyung Wang Jieun Kim Kummara Madhusudana Rao Soo Yong Park Ildoo Chung Chang-Sik Ha Sang-Woo Kim Yang H. Yun Youngmi Jung
author_sort	Jeongeun Hyun
title	MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
title_short	MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
title_full	MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
title_fullStr	MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
title_full_unstemmed	MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
title_sort	microrna-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing gli3 expression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4f54381c8f96469a82e5f4d6d35090c7
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MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

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