MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

Liver fibrosis is a pathogenic driver of many liver diseases, so understanding its regulation might open the door to new therapies. Here the authors perform a screen for miRNA candidates and identify that miR-378 inhibits liver fibrosis in mice by interfering with Hedgehog signalling in hepatic stel...

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Autores principales: Jeongeun Hyun, Sihyung Wang, Jieun Kim, Kummara Madhusudana Rao, Soo Yong Park, Ildoo Chung, Chang-Sik Ha, Sang-Woo Kim, Yang H. Yun, Youngmi Jung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4f54381c8f96469a82e5f4d6d35090c7
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