Bacterial lipopolysaccharide is associated with stroke

Abstract We aimed to determine if plasma levels of bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) are associated with different causes of stroke and correlate with C-reactive protein (CRP), LPS-binding protein (LBP), and the NIH stroke scale (NIHSS). Ischemic stroke (cardioembolic (C...

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Autores principales:	Marisa Hakoupian, Eva Ferino, Glen C. Jickling, Hajar Amini, Boryana Stamova, Bradley P. Ander, Noor Alomar, Frank R. Sharp, Xinhua Zhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f588642933a4edcaf3b8155f695c074
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spelling	oai:doaj.org-article:4f588642933a4edcaf3b8155f695c0742021-12-02T16:36:05ZBacterial lipopolysaccharide is associated with stroke10.1038/s41598-021-86083-82045-2322https://doaj.org/article/4f588642933a4edcaf3b8155f695c0742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86083-8https://doaj.org/toc/2045-2322Abstract We aimed to determine if plasma levels of bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) are associated with different causes of stroke and correlate with C-reactive protein (CRP), LPS-binding protein (LBP), and the NIH stroke scale (NIHSS). Ischemic stroke (cardioembolic (CE), large artery atherosclerosis (LAA), small vessel occlusion (SVO)), intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and control subjects were compared (n = 205). Plasma LPS, LTA, CRP, and LBP levels were quantified by ELISA. LPS and CRP levels were elevated in ischemic strokes (CE, LAA, SVO) and ICH compared to controls. LBP levels were elevated in ischemic strokes (CE, LAA) and ICH. LTA levels were increased in SVO stroke compared to TIA but not controls. LPS levels correlated with CRP and LBP levels in stroke and TIA. LPS, LBP and CRP levels positively correlated with the NIHSS and WBC count but negatively correlated with total cholesterol. Plasma LPS and LBP associate with major causes of ischemic stroke and with ICH, whereas LPS/LBP do not associate with TIAs. LTA only associated with SVO stroke. LPS positively correlated with CRP, LBP, and WBC but negatively correlated with cholesterol. Higher LPS levels were associated with worse stroke outcomes.Marisa HakoupianEva FerinoGlen C. JicklingHajar AminiBoryana StamovaBradley P. AnderNoor AlomarFrank R. SharpXinhua ZhanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marisa Hakoupian Eva Ferino Glen C. Jickling Hajar Amini Boryana Stamova Bradley P. Ander Noor Alomar Frank R. Sharp Xinhua Zhan Bacterial lipopolysaccharide is associated with stroke
description	Abstract We aimed to determine if plasma levels of bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) are associated with different causes of stroke and correlate with C-reactive protein (CRP), LPS-binding protein (LBP), and the NIH stroke scale (NIHSS). Ischemic stroke (cardioembolic (CE), large artery atherosclerosis (LAA), small vessel occlusion (SVO)), intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and control subjects were compared (n = 205). Plasma LPS, LTA, CRP, and LBP levels were quantified by ELISA. LPS and CRP levels were elevated in ischemic strokes (CE, LAA, SVO) and ICH compared to controls. LBP levels were elevated in ischemic strokes (CE, LAA) and ICH. LTA levels were increased in SVO stroke compared to TIA but not controls. LPS levels correlated with CRP and LBP levels in stroke and TIA. LPS, LBP and CRP levels positively correlated with the NIHSS and WBC count but negatively correlated with total cholesterol. Plasma LPS and LBP associate with major causes of ischemic stroke and with ICH, whereas LPS/LBP do not associate with TIAs. LTA only associated with SVO stroke. LPS positively correlated with CRP, LBP, and WBC but negatively correlated with cholesterol. Higher LPS levels were associated with worse stroke outcomes.
format	article
author	Marisa Hakoupian Eva Ferino Glen C. Jickling Hajar Amini Boryana Stamova Bradley P. Ander Noor Alomar Frank R. Sharp Xinhua Zhan
author_facet	Marisa Hakoupian Eva Ferino Glen C. Jickling Hajar Amini Boryana Stamova Bradley P. Ander Noor Alomar Frank R. Sharp Xinhua Zhan
author_sort	Marisa Hakoupian
title	Bacterial lipopolysaccharide is associated with stroke
title_short	Bacterial lipopolysaccharide is associated with stroke
title_full	Bacterial lipopolysaccharide is associated with stroke
title_fullStr	Bacterial lipopolysaccharide is associated with stroke
title_full_unstemmed	Bacterial lipopolysaccharide is associated with stroke
title_sort	bacterial lipopolysaccharide is associated with stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4f588642933a4edcaf3b8155f695c074
work_keys_str_mv	AT marisahakoupian bacteriallipopolysaccharideisassociatedwithstroke AT evaferino bacteriallipopolysaccharideisassociatedwithstroke AT glencjickling bacteriallipopolysaccharideisassociatedwithstroke AT hajaramini bacteriallipopolysaccharideisassociatedwithstroke AT boryanastamova bacteriallipopolysaccharideisassociatedwithstroke AT bradleypander bacteriallipopolysaccharideisassociatedwithstroke AT nooralomar bacteriallipopolysaccharideisassociatedwithstroke AT frankrsharp bacteriallipopolysaccharideisassociatedwithstroke AT xinhuazhan bacteriallipopolysaccharideisassociatedwithstroke
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Bacterial lipopolysaccharide is associated with stroke

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