Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network

Abstract Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a “fatigue network”. These include the striatum of t...

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Autores principales:	G. R. Wylie, B. Yao, H. M. Genova, M. H. Chen, J. DeLuca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f5b3b3bc96847de8085ea3549437da3
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spelling	oai:doaj.org-article:4f5b3b3bc96847de8085ea3549437da32021-12-02T13:33:59ZUsing functional connectivity changes associated with cognitive fatigue to delineate a fatigue network10.1038/s41598-020-78768-32045-2322https://doaj.org/article/4f5b3b3bc96847de8085ea3549437da32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78768-3https://doaj.org/toc/2045-2322Abstract Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a “fatigue network”. These include the striatum of the basal ganglia, the dorsolateral prefrontal cortex (DLPFC), the dorsal anterior cingulate cortex (dACC), the ventro-medial prefrontal cortex (vmPFC) and the anterior insula. However, no work has been conducted to assess whether the connectivity between these regions changes as a function of cognitive fatigue. We used a task-based functional neuroimaging paradigm to induce fatigue in 39 healthy individuals, regressed the signal associated with the task out of the data, and investigated how the functional connectivity between these regions changed as cognitive fatigue increased. We observed functional connectivity between these regions and other frontal regions largely decreased as cognitive fatigue increased while connectivity between these seeds and more posterior regions increased. Furthermore the striatum, the DLPFC, the insula and the vmPFC appeared to be central ‘nodes’ or hubs of the fatigue network. These findings represent the first demonstration that the functional connectivity between these areas changes as a function of cognitive fatigue.G. R. WylieB. YaoH. M. GenovaM. H. ChenJ. DeLucaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q G. R. Wylie B. Yao H. M. Genova M. H. Chen J. DeLuca Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
description	Abstract Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a “fatigue network”. These include the striatum of the basal ganglia, the dorsolateral prefrontal cortex (DLPFC), the dorsal anterior cingulate cortex (dACC), the ventro-medial prefrontal cortex (vmPFC) and the anterior insula. However, no work has been conducted to assess whether the connectivity between these regions changes as a function of cognitive fatigue. We used a task-based functional neuroimaging paradigm to induce fatigue in 39 healthy individuals, regressed the signal associated with the task out of the data, and investigated how the functional connectivity between these regions changed as cognitive fatigue increased. We observed functional connectivity between these regions and other frontal regions largely decreased as cognitive fatigue increased while connectivity between these seeds and more posterior regions increased. Furthermore the striatum, the DLPFC, the insula and the vmPFC appeared to be central ‘nodes’ or hubs of the fatigue network. These findings represent the first demonstration that the functional connectivity between these areas changes as a function of cognitive fatigue.
format	article
author	G. R. Wylie B. Yao H. M. Genova M. H. Chen J. DeLuca
author_facet	G. R. Wylie B. Yao H. M. Genova M. H. Chen J. DeLuca
author_sort	G. R. Wylie
title	Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
title_short	Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
title_full	Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
title_fullStr	Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
title_full_unstemmed	Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
title_sort	using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4f5b3b3bc96847de8085ea3549437da3
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Using functional connectivity changes associated with cognitive fatigue to delineate a fatigue network

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