A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment

Raymond L Ownby,1 Amarilis Acevedo2 1Department of Psychiatry and Behavioral Medicine, 2College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA Background: In spite of treatment advances, HIV infection is associated with cognitive deficits. This is even more...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ownby RL, Acevedo A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	HIV transcranial direct current stimulation tDCS cognitive aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4f5da511e11847e2a1c6c68f7942dbdb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f5da511e11847e2a1c6c68f7942dbdb
record_format	dspace
spelling	oai:doaj.org-article:4f5da511e11847e2a1c6c68f7942dbdb2021-12-02T08:33:39ZA pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment1178-2021https://doaj.org/article/4f5da511e11847e2a1c6c68f7942dbdb2016-10-01T00:00:00Zhttps://www.dovepress.com/a-pilot-study-of-cognitive-training-with-and-without-transcranial-dire-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Raymond L Ownby,1 Amarilis Acevedo2 1Department of Psychiatry and Behavioral Medicine, 2College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA Background: In spite of treatment advances, HIV infection is associated with cognitive deficits. This is even more important as many persons with HIV infection age and experience age-related cognitive impairments. Both computer-based cognitive training and transcranial direct current stimulation (tDCS) have shown promise as interventions to improve cognitive function. In this study, we investigate the acceptability and efficacy of cognitive training with and without tDCS in older persons with HIV. Patients and methods: In this single-blind randomized study, participants were 14 individuals of whom 11 completed study procedures (mean age =51.5 years; nine men and two women) with HIV-related mild neurocognitive disorder. Participants completed a battery of neuropsychological and self-report measures and then six 20-minute cognitive training sessions while receiving either active or sham anodal tDCS over the left dorsolateral prefrontal cortex. After training, participants completed the same measures. Success of the blind and participant reactions were assessed during a final interview. Assessments were completed by an assessor blind to treatment assignment. Pre- and post-training changes were evaluated via analysis of covariance yielding estimates of effect size. Results: All participants believed that they had been assigned to active treatment; nine of the 11 believed that the intervention had improved their cognitive functioning. Both participants who felt the intervention was ineffective were assigned to the sham condition. None of the planned tested interactions of time with treatment was significant, but 12 of 13 favored tDCS (P=0.08). All participants indicated that they would participate in similar studies in the future. Conclusion: Results show that both cognitive training via computer game playing and tDCS were well accepted by older persons with HIV infection. Results are suggestive that tDCS may improve cognitive function in persons with HIV infection. Further study of tDCS as an intervention for HIV-related cognitive dysfunction is warranted. Keywords: HIV, transcranial direct current stimulation, tDCS, cognitive agingOwnby RLAcevedo ADove Medical PressarticleHIVtranscranial direct current stimulationtDCScognitive agingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2745-2754 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV transcranial direct current stimulation tDCS cognitive aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	HIV transcranial direct current stimulation tDCS cognitive aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ownby RL Acevedo A A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment
description	Raymond L Ownby,1 Amarilis Acevedo2 1Department of Psychiatry and Behavioral Medicine, 2College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA Background: In spite of treatment advances, HIV infection is associated with cognitive deficits. This is even more important as many persons with HIV infection age and experience age-related cognitive impairments. Both computer-based cognitive training and transcranial direct current stimulation (tDCS) have shown promise as interventions to improve cognitive function. In this study, we investigate the acceptability and efficacy of cognitive training with and without tDCS in older persons with HIV. Patients and methods: In this single-blind randomized study, participants were 14 individuals of whom 11 completed study procedures (mean age =51.5 years; nine men and two women) with HIV-related mild neurocognitive disorder. Participants completed a battery of neuropsychological and self-report measures and then six 20-minute cognitive training sessions while receiving either active or sham anodal tDCS over the left dorsolateral prefrontal cortex. After training, participants completed the same measures. Success of the blind and participant reactions were assessed during a final interview. Assessments were completed by an assessor blind to treatment assignment. Pre- and post-training changes were evaluated via analysis of covariance yielding estimates of effect size. Results: All participants believed that they had been assigned to active treatment; nine of the 11 believed that the intervention had improved their cognitive functioning. Both participants who felt the intervention was ineffective were assigned to the sham condition. None of the planned tested interactions of time with treatment was significant, but 12 of 13 favored tDCS (P=0.08). All participants indicated that they would participate in similar studies in the future. Conclusion: Results show that both cognitive training via computer game playing and tDCS were well accepted by older persons with HIV infection. Results are suggestive that tDCS may improve cognitive function in persons with HIV infection. Further study of tDCS as an intervention for HIV-related cognitive dysfunction is warranted. Keywords: HIV, transcranial direct current stimulation, tDCS, cognitive aging
format	article
author	Ownby RL Acevedo A
author_facet	Ownby RL Acevedo A
author_sort	Ownby RL
title	A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment
title_short	A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment
title_full	A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment
title_fullStr	A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment
title_full_unstemmed	A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment
title_sort	pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with hiv-related cognitive impairment
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/4f5da511e11847e2a1c6c68f7942dbdb
work_keys_str_mv	AT ownbyrl apilotstudyofcognitivetrainingwithandwithouttranscranialdirectcurrentstimulationtoimprovecognitioninolderpersonswithhivrelatedcognitiveimpairment AT acevedoa apilotstudyofcognitivetrainingwithandwithouttranscranialdirectcurrentstimulationtoimprovecognitioninolderpersonswithhivrelatedcognitiveimpairment AT ownbyrl pilotstudyofcognitivetrainingwithandwithouttranscranialdirectcurrentstimulationtoimprovecognitioninolderpersonswithhivrelatedcognitiveimpairment AT acevedoa pilotstudyofcognitivetrainingwithandwithouttranscranialdirectcurrentstimulationtoimprovecognitioninolderpersonswithhivrelatedcognitiveimpairment
_version_	1718398481945591808

A pilot study of cognitive training with and without transcranial direct current stimulation to improve cognition in older persons with HIV-related cognitive impairment

Ejemplares similares