Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, pot...

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Autores principales:	Jung-Hwan Kim, Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia, Christopher J. Chang, Heejung Yang, Tomokazu Nagano, Kristopher W. Krausz, Sun-Hee Yim, Frank J. Gonzalez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4f6071cc15e246109373c004d13bfa3a
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spelling	oai:doaj.org-article:4f6071cc15e246109373c004d13bfa3a2021-12-02T14:11:45ZLysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis10.1038/s41467-020-20461-02041-1723https://doaj.org/article/4f6071cc15e246109373c004d13bfa3a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20461-0https://doaj.org/toc/2041-1723The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function.Jung-Hwan KimTsutomu MatsubaraJaekwon LeeCristina Fenollar-FerrerKyungreem HanDonghwan KimShang JiaChristopher J. ChangHeejung YangTomokazu NaganoKristopher W. KrauszSun-Hee YimFrank J. GonzalezNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Hwan Kim Tsutomu Matsubara Jaekwon Lee Cristina Fenollar-Ferrer Kyungreem Han Donghwan Kim Shang Jia Christopher J. Chang Heejung Yang Tomokazu Nagano Kristopher W. Krausz Sun-Hee Yim Frank J. Gonzalez Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
description	The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes hepatic toxicity associated with prominent lipid accumulation in humans. Here, the authors report that the lysosomal copper transporter SLC46A3 is induced by TCDD and underlies the hepatic lipid accumulation in mice, potentially via effects on mitochondrial function.
format	article
author	Jung-Hwan Kim Tsutomu Matsubara Jaekwon Lee Cristina Fenollar-Ferrer Kyungreem Han Donghwan Kim Shang Jia Christopher J. Chang Heejung Yang Tomokazu Nagano Kristopher W. Krausz Sun-Hee Yim Frank J. Gonzalez
author_facet	Jung-Hwan Kim Tsutomu Matsubara Jaekwon Lee Cristina Fenollar-Ferrer Kyungreem Han Donghwan Kim Shang Jia Christopher J. Chang Heejung Yang Tomokazu Nagano Kristopher W. Krausz Sun-Hee Yim Frank J. Gonzalez
author_sort	Jung-Hwan Kim
title	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_short	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_full	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_fullStr	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_full_unstemmed	Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
title_sort	lysosomal slc46a3 modulates hepatic cytosolic copper homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4f6071cc15e246109373c004d13bfa3a
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Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis

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