Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer

N6-Methyladenosine (m6A) is the most abundant modifications in human messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer(PCa). The expression level of FTO in PCa was detected by q...

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Autores principales:	Sheng Li, Lin Cao
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	prostate cancer fto mc4r m6a malignant progression Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/4f6a784e677e46f8bdc16554d532f72c
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spelling	oai:doaj.org-article:4f6a784e677e46f8bdc16554d532f72c2021-11-26T11:19:49ZDemethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer2165-59792165-598710.1080/21655979.2021.2001936https://doaj.org/article/4f6a784e677e46f8bdc16554d532f72c2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2001936https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987N6-Methyladenosine (m6A) is the most abundant modifications in human messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer(PCa). The expression level of FTO in PCa was detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot. Besides, the impacts of FTO on the proliferation, migration and invasion of PCa cells were also detected by cell counting kit-8 (CCK-8), 5-ethynyl-2ʹ-deoxyuridine (EdU) and transwell assays. Furthermore, we also explored the potential mechanism of FTO in PCa. The results showed that FTO expression was decreased in PCa, and the low expression of FTO showed an obvious relevance to the clinical characteristics. Downregulation of FTO facilitated the proliferation, migration, invasion and tumor growth of PCa cells. Besides, MC4R displayed a remarkably high expression in PCa tissues, whose expression and m6A level were regulated by FTO. Meanwhile, the in vitro experiments revealed that highly expressed FTO partially reversed the facilitating effect of highly expressed MC4R on the malignant phenotype of PCa cells. Overall, FTO was downregulated in PCa and its expression level showed a relevance to the prognosis of PCa patients. Additionally, FTO could regulate the proliferation, migration and invasion of PCa via regulating the expression level of MC4R.Sheng LiLin CaoTaylor & Francis Grouparticleprostate cancerftomc4rm6amalignant progressionBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer fto mc4r m6a malignant progression Biotechnology TP248.13-248.65
spellingShingle	prostate cancer fto mc4r m6a malignant progression Biotechnology TP248.13-248.65 Sheng Li Lin Cao Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer
description	N6-Methyladenosine (m6A) is the most abundant modifications in human messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer(PCa). The expression level of FTO in PCa was detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blot. Besides, the impacts of FTO on the proliferation, migration and invasion of PCa cells were also detected by cell counting kit-8 (CCK-8), 5-ethynyl-2ʹ-deoxyuridine (EdU) and transwell assays. Furthermore, we also explored the potential mechanism of FTO in PCa. The results showed that FTO expression was decreased in PCa, and the low expression of FTO showed an obvious relevance to the clinical characteristics. Downregulation of FTO facilitated the proliferation, migration, invasion and tumor growth of PCa cells. Besides, MC4R displayed a remarkably high expression in PCa tissues, whose expression and m6A level were regulated by FTO. Meanwhile, the in vitro experiments revealed that highly expressed FTO partially reversed the facilitating effect of highly expressed MC4R on the malignant phenotype of PCa cells. Overall, FTO was downregulated in PCa and its expression level showed a relevance to the prognosis of PCa patients. Additionally, FTO could regulate the proliferation, migration and invasion of PCa via regulating the expression level of MC4R.
format	article
author	Sheng Li Lin Cao
author_facet	Sheng Li Lin Cao
author_sort	Sheng Li
title	Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer
title_short	Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer
title_full	Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer
title_fullStr	Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer
title_full_unstemmed	Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (MC4R): Running title: FTO inhibits the proliferation, migration and invasion of prostate cancer
title_sort	demethyltransferase fto alpha-ketoglutarate dependent dioxygenase (fto) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by modulating the expression of melanocortin 4 receptor (mc4r): running title: fto inhibits the proliferation, migration and invasion of prostate cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/4f6a784e677e46f8bdc16554d532f72c
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