Bilateral corneal ulceration in ocular graft-versus-host disease

William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series inve...

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Autores principales: Stevenson W, Shikari H, Saboo US, Amparo F, Dana R
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Lenguaje:EN
Publicado: Dove Medical Press 2013
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Acceso en línea:https://doaj.org/article/4f711defb08b476e980b6a1e0d3e3b71
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spelling oai:doaj.org-article:4f711defb08b476e980b6a1e0d3e3b712021-12-02T06:27:29ZBilateral corneal ulceration in ocular graft-versus-host disease1177-54671177-5483https://doaj.org/article/4f711defb08b476e980b6a1e0d3e3b712013-10-01T00:00:00Zhttp://www.dovepress.com/bilateral-corneal-ulceration-in-ocular-graft-versus-host-disease-a14849https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series investigating corneal ulceration and perforation in a cohort of ocular GVHD patients seen between June 2007 and October 2012. Results: Four of 243 ocular GVHD patients developed corneal ulcerations attributable to ocular GVHD, and all four cases involved bilateral corneal ulceration. The median length of time from the diagnosis of ocular GVHD to the diagnosis of the first corneal ulceration was 317 days (range 168–434). The median length of time between the diagnosis of corneal ulceration in each patient's first and second eye was 248 days (range 9–645). Outcomes varied from complete resolution with medical treatment to corneal perforation necessitating penetrating keratoplasty. In cases of corneal perforation, the median length of time from the diagnosis of corneal ulceration to perforation was 10 days (range 0–20). Common clinical features included: centrally or paracentrally located ulcerations and perforations, concomitant dry eye, and the use of topical or systemic corticosteroids. Conclusion: Frequent follow-up and bilateral monitoring are highly recommended in cases of ocular GVHD-associated stromal thinning, as bilateral involvement or rapid progression to corneal perforation can occur. Keywords: graft-versus-host disease, ocular graft-versus-host disease, corneal ulceration, corneal perforationStevenson WShikari HSaboo USAmparo FDana RDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2153-2158 (2013)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Stevenson W
Shikari H
Saboo US
Amparo F
Dana R
Bilateral corneal ulceration in ocular graft-versus-host disease
description William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series investigating corneal ulceration and perforation in a cohort of ocular GVHD patients seen between June 2007 and October 2012. Results: Four of 243 ocular GVHD patients developed corneal ulcerations attributable to ocular GVHD, and all four cases involved bilateral corneal ulceration. The median length of time from the diagnosis of ocular GVHD to the diagnosis of the first corneal ulceration was 317 days (range 168–434). The median length of time between the diagnosis of corneal ulceration in each patient's first and second eye was 248 days (range 9–645). Outcomes varied from complete resolution with medical treatment to corneal perforation necessitating penetrating keratoplasty. In cases of corneal perforation, the median length of time from the diagnosis of corneal ulceration to perforation was 10 days (range 0–20). Common clinical features included: centrally or paracentrally located ulcerations and perforations, concomitant dry eye, and the use of topical or systemic corticosteroids. Conclusion: Frequent follow-up and bilateral monitoring are highly recommended in cases of ocular GVHD-associated stromal thinning, as bilateral involvement or rapid progression to corneal perforation can occur. Keywords: graft-versus-host disease, ocular graft-versus-host disease, corneal ulceration, corneal perforation
format article
author Stevenson W
Shikari H
Saboo US
Amparo F
Dana R
author_facet Stevenson W
Shikari H
Saboo US
Amparo F
Dana R
author_sort Stevenson W
title Bilateral corneal ulceration in ocular graft-versus-host disease
title_short Bilateral corneal ulceration in ocular graft-versus-host disease
title_full Bilateral corneal ulceration in ocular graft-versus-host disease
title_fullStr Bilateral corneal ulceration in ocular graft-versus-host disease
title_full_unstemmed Bilateral corneal ulceration in ocular graft-versus-host disease
title_sort bilateral corneal ulceration in ocular graft-versus-host disease
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/4f711defb08b476e980b6a1e0d3e3b71
work_keys_str_mv AT stevensonw bilateralcornealulcerationinoculargraftversushostdisease
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AT saboous bilateralcornealulcerationinoculargraftversushostdisease
AT amparof bilateralcornealulcerationinoculargraftversushostdisease
AT danar bilateralcornealulcerationinoculargraftversushostdisease
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