Bilateral corneal ulceration in ocular graft-versus-host disease
William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series inve...
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Dove Medical Press
2013
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oai:doaj.org-article:4f711defb08b476e980b6a1e0d3e3b712021-12-02T06:27:29ZBilateral corneal ulceration in ocular graft-versus-host disease1177-54671177-5483https://doaj.org/article/4f711defb08b476e980b6a1e0d3e3b712013-10-01T00:00:00Zhttp://www.dovepress.com/bilateral-corneal-ulceration-in-ocular-graft-versus-host-disease-a14849https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series investigating corneal ulceration and perforation in a cohort of ocular GVHD patients seen between June 2007 and October 2012. Results: Four of 243 ocular GVHD patients developed corneal ulcerations attributable to ocular GVHD, and all four cases involved bilateral corneal ulceration. The median length of time from the diagnosis of ocular GVHD to the diagnosis of the first corneal ulceration was 317 days (range 168–434). The median length of time between the diagnosis of corneal ulceration in each patient's first and second eye was 248 days (range 9–645). Outcomes varied from complete resolution with medical treatment to corneal perforation necessitating penetrating keratoplasty. In cases of corneal perforation, the median length of time from the diagnosis of corneal ulceration to perforation was 10 days (range 0–20). Common clinical features included: centrally or paracentrally located ulcerations and perforations, concomitant dry eye, and the use of topical or systemic corticosteroids. Conclusion: Frequent follow-up and bilateral monitoring are highly recommended in cases of ocular GVHD-associated stromal thinning, as bilateral involvement or rapid progression to corneal perforation can occur. Keywords: graft-versus-host disease, ocular graft-versus-host disease, corneal ulceration, corneal perforationStevenson WShikari HSaboo USAmparo FDana RDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2153-2158 (2013) |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Stevenson W Shikari H Saboo US Amparo F Dana R Bilateral corneal ulceration in ocular graft-versus-host disease |
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William Stevenson, Hasanain Shikari, Ujwala S Saboo, Francisco Amparo, Reza Dana Cornea Service, Massachusetts Eye and Ear Infirmary, Boston, MA, USA Purpose: To report on corneal ulceration in ocular graft-versus-host disease (GVHD). Methods: This was a retrospective, observational case series investigating corneal ulceration and perforation in a cohort of ocular GVHD patients seen between June 2007 and October 2012. Results: Four of 243 ocular GVHD patients developed corneal ulcerations attributable to ocular GVHD, and all four cases involved bilateral corneal ulceration. The median length of time from the diagnosis of ocular GVHD to the diagnosis of the first corneal ulceration was 317 days (range 168–434). The median length of time between the diagnosis of corneal ulceration in each patient's first and second eye was 248 days (range 9–645). Outcomes varied from complete resolution with medical treatment to corneal perforation necessitating penetrating keratoplasty. In cases of corneal perforation, the median length of time from the diagnosis of corneal ulceration to perforation was 10 days (range 0–20). Common clinical features included: centrally or paracentrally located ulcerations and perforations, concomitant dry eye, and the use of topical or systemic corticosteroids. Conclusion: Frequent follow-up and bilateral monitoring are highly recommended in cases of ocular GVHD-associated stromal thinning, as bilateral involvement or rapid progression to corneal perforation can occur. Keywords: graft-versus-host disease, ocular graft-versus-host disease, corneal ulceration, corneal perforation |
format |
article |
author |
Stevenson W Shikari H Saboo US Amparo F Dana R |
author_facet |
Stevenson W Shikari H Saboo US Amparo F Dana R |
author_sort |
Stevenson W |
title |
Bilateral corneal ulceration in ocular graft-versus-host disease |
title_short |
Bilateral corneal ulceration in ocular graft-versus-host disease |
title_full |
Bilateral corneal ulceration in ocular graft-versus-host disease |
title_fullStr |
Bilateral corneal ulceration in ocular graft-versus-host disease |
title_full_unstemmed |
Bilateral corneal ulceration in ocular graft-versus-host disease |
title_sort |
bilateral corneal ulceration in ocular graft-versus-host disease |
publisher |
Dove Medical Press |
publishDate |
2013 |
url |
https://doaj.org/article/4f711defb08b476e980b6a1e0d3e3b71 |
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