Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer

Contribution of p53 in sensitivity to EGFR tyrosine kinase inhibitors in non-small cell lung cancer

Abstract The emergence of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) with activating EGFR mutations is a major hindrance to treatment. We investigated the effects of p53 in primary sensitivity and acquired resistance...

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Bibliographic Details
Main Authors: Sangyong Jung, Dong Ha Kim, Yun Jung Choi, Seon Ye Kim, Hyojeong Park, Hyeonjeong Lee, Chang-Min Choi, Young Hoon Sung, Jae Cheol Lee, Jin Kyung Rho
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/4f71769b43da4ae2a10dadce8fbefd82
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