Neonatal dengue as never before - A case series

Dengue is a Flavivirus, affecting about 100 million people annually and mainly in the tropical and subtropical countries. Neonatal dengue is uncommon and usually by vertical transmission or, in the postnatal period, by horizontal transmission. We describe the clinical profile, management and outcome...

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Autores principales:	Alimelu Madireddi, Vinod Kumar Mandala, Narahari Bapanpally, Rakesh Kotha, Kalyan Chakravarthy Konda, R Haripriya
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	dengue fever neonate management outcome Medicine R
Acceso en línea:	https://doaj.org/article/4f73c3155f6d4dfba4e0a3ee4d33e33f
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spelling	oai:doaj.org-article:4f73c3155f6d4dfba4e0a3ee4d33e33f2021-11-12T11:15:00ZNeonatal dengue as never before - A case series2321-668910.4103/smj.smj_41_20https://doaj.org/article/4f73c3155f6d4dfba4e0a3ee4d33e33f2021-01-01T00:00:00Zhttp://www.smjonline.org/article.asp?issn=1118-8561;year=2021;volume=24;issue=3;spage=140;epage=144;aulast=Madireddihttps://doaj.org/toc/2321-6689Dengue is a Flavivirus, affecting about 100 million people annually and mainly in the tropical and subtropical countries. Neonatal dengue is uncommon and usually by vertical transmission or, in the postnatal period, by horizontal transmission. We describe the clinical profile, management and outcome of neonates with dengue infection. Ten patients were prospectively recruited from August to November 2019 during dengue epidemic season at Niloufer Hospital, Hyderabad, India. Four babies had vertical mode of transmission while 6 had horizontal mode of transmission. All babies were positive for Ns1 antigen and IgM dengue serology, confirming dengue infection. Fever, flushing and thrombocytopenia were observed in all the babies while 2 babies had hypotension requiring inotropes. Oxygen supplementation was required in 8 babies. There was no recorded mortality. We conclude that neonatal dengue should be considered as a differential diagnosis in a neonate with sepsis and thrombocytopenia especially in endemic regions. Judicious use of fluids (avoid excessive) and inotropes (dopamine) form the cornerstone of dengue management in neonates.Alimelu MadireddiVinod Kumar MandalaNarahari BapanpallyRakesh KothaKalyan Chakravarthy KondaR HaripriyaWolters Kluwer Medknow Publicationsarticledengue feverneonatemanagementoutcomeMedicineRENSahel Medical Journal, Vol 24, Iss 3, Pp 140-144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dengue fever neonate management outcome Medicine R
spellingShingle	dengue fever neonate management outcome Medicine R Alimelu Madireddi Vinod Kumar Mandala Narahari Bapanpally Rakesh Kotha Kalyan Chakravarthy Konda R Haripriya Neonatal dengue as never before - A case series
description	Dengue is a Flavivirus, affecting about 100 million people annually and mainly in the tropical and subtropical countries. Neonatal dengue is uncommon and usually by vertical transmission or, in the postnatal period, by horizontal transmission. We describe the clinical profile, management and outcome of neonates with dengue infection. Ten patients were prospectively recruited from August to November 2019 during dengue epidemic season at Niloufer Hospital, Hyderabad, India. Four babies had vertical mode of transmission while 6 had horizontal mode of transmission. All babies were positive for Ns1 antigen and IgM dengue serology, confirming dengue infection. Fever, flushing and thrombocytopenia were observed in all the babies while 2 babies had hypotension requiring inotropes. Oxygen supplementation was required in 8 babies. There was no recorded mortality. We conclude that neonatal dengue should be considered as a differential diagnosis in a neonate with sepsis and thrombocytopenia especially in endemic regions. Judicious use of fluids (avoid excessive) and inotropes (dopamine) form the cornerstone of dengue management in neonates.
format	article
author	Alimelu Madireddi Vinod Kumar Mandala Narahari Bapanpally Rakesh Kotha Kalyan Chakravarthy Konda R Haripriya
author_facet	Alimelu Madireddi Vinod Kumar Mandala Narahari Bapanpally Rakesh Kotha Kalyan Chakravarthy Konda R Haripriya
author_sort	Alimelu Madireddi
title	Neonatal dengue as never before - A case series
title_short	Neonatal dengue as never before - A case series
title_full	Neonatal dengue as never before - A case series
title_fullStr	Neonatal dengue as never before - A case series
title_full_unstemmed	Neonatal dengue as never before - A case series
title_sort	neonatal dengue as never before - a case series
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/4f73c3155f6d4dfba4e0a3ee4d33e33f
work_keys_str_mv	AT alimelumadireddi neonataldengueasneverbeforeacaseseries AT vinodkumarmandala neonataldengueasneverbeforeacaseseries AT naraharibapanpally neonataldengueasneverbeforeacaseseries AT rakeshkotha neonataldengueasneverbeforeacaseseries AT kalyanchakravarthykonda neonataldengueasneverbeforeacaseseries AT rharipriya neonataldengueasneverbeforeacaseseries
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Neonatal dengue as never before - A case series

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