Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature

Abstract Background Apocrine carcinoma is a rare tumor that constitutes < 4% of all breast malignancies, characterized by the proliferation of large atypical cells with strictly defined borders, abundant eosinophilic cytoplasm, large nuclei, and prominent nucleoli in more than 90% of tumor cells....

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Autores principales:	Sawsan Ismail, Haidara Kherbek, Jana Skef, Nadim Zahlouk, Rafik Abdulal, Zuheir Alshehabi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Apocrine carcinoma Triple-negative apocrine carcinoma Apocrine differentiation Immunohistochemistry Breast Cancer Gynecology and obstetrics RG1-991 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/4f7616ff116e447286e4b5566db79e67
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spelling	oai:doaj.org-article:4f7616ff116e447286e4b5566db79e672021-11-28T12:10:33ZTriple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature10.1186/s12905-021-01539-31472-6874https://doaj.org/article/4f7616ff116e447286e4b5566db79e672021-11-01T00:00:00Zhttps://doi.org/10.1186/s12905-021-01539-3https://doaj.org/toc/1472-6874Abstract Background Apocrine carcinoma is a rare tumor that constitutes < 4% of all breast malignancies, characterized by the proliferation of large atypical cells with strictly defined borders, abundant eosinophilic cytoplasm, large nuclei, and prominent nucleoli in more than 90% of tumor cells. Triple-negative apocrine carcinoma is a rare molecular subtype that constitutes less than 1% of triple-negative breast cancers and is characterized by negative expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor, with positive expression of androgen receptor. Case presentation We report a case of a 45-year-old Syrian female who presented to our hospital due to a painless palpable mass in her left breast. Following physical and radiological examinations, an excisional biopsy was performed. Microscopic examination of the specimen followed by immunohistochemical staining revealed the diagnosis of a triple-negative apocrine carcinoma. Conclusion Triple-negative apocrine carcinoma is an extremely rare neoplasm that must be considered in the differential diagnoses of breast lesions through detailed clinical, histological, and immunohistochemical correlations. In our manuscript, we aimed to present the first case report of a Syrian female who was diagnosed with a triple-negative apocrine carcinoma, aiming to highlight the importance of detailed clinical, histological and immunohistochemical correlations with a detailed review of diagnostic criteria, molecular characteristics, and treatment recommendations.Sawsan IsmailHaidara KherbekJana SkefNadim ZahloukRafik AbdulalZuheir AlshehabiBMCarticleApocrine carcinomaTriple-negative apocrine carcinomaApocrine differentiationImmunohistochemistryBreast CancerGynecology and obstetricsRG1-991Public aspects of medicineRA1-1270ENBMC Women's Health, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Apocrine carcinoma Triple-negative apocrine carcinoma Apocrine differentiation Immunohistochemistry Breast Cancer Gynecology and obstetrics RG1-991 Public aspects of medicine RA1-1270
spellingShingle	Apocrine carcinoma Triple-negative apocrine carcinoma Apocrine differentiation Immunohistochemistry Breast Cancer Gynecology and obstetrics RG1-991 Public aspects of medicine RA1-1270 Sawsan Ismail Haidara Kherbek Jana Skef Nadim Zahlouk Rafik Abdulal Zuheir Alshehabi Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature
description	Abstract Background Apocrine carcinoma is a rare tumor that constitutes < 4% of all breast malignancies, characterized by the proliferation of large atypical cells with strictly defined borders, abundant eosinophilic cytoplasm, large nuclei, and prominent nucleoli in more than 90% of tumor cells. Triple-negative apocrine carcinoma is a rare molecular subtype that constitutes less than 1% of triple-negative breast cancers and is characterized by negative expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor, with positive expression of androgen receptor. Case presentation We report a case of a 45-year-old Syrian female who presented to our hospital due to a painless palpable mass in her left breast. Following physical and radiological examinations, an excisional biopsy was performed. Microscopic examination of the specimen followed by immunohistochemical staining revealed the diagnosis of a triple-negative apocrine carcinoma. Conclusion Triple-negative apocrine carcinoma is an extremely rare neoplasm that must be considered in the differential diagnoses of breast lesions through detailed clinical, histological, and immunohistochemical correlations. In our manuscript, we aimed to present the first case report of a Syrian female who was diagnosed with a triple-negative apocrine carcinoma, aiming to highlight the importance of detailed clinical, histological and immunohistochemical correlations with a detailed review of diagnostic criteria, molecular characteristics, and treatment recommendations.
format	article
author	Sawsan Ismail Haidara Kherbek Jana Skef Nadim Zahlouk Rafik Abdulal Zuheir Alshehabi
author_facet	Sawsan Ismail Haidara Kherbek Jana Skef Nadim Zahlouk Rafik Abdulal Zuheir Alshehabi
author_sort	Sawsan Ismail
title	Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature
title_short	Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature
title_full	Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature
title_fullStr	Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature
title_full_unstemmed	Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature
title_sort	triple-negative apocrine carcinoma as a rare cause of a breast lump in a syrian female: a case report and review of the literature
publisher	BMC
publishDate	2021
url	https://doaj.org/article/4f7616ff116e447286e4b5566db79e67
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Triple-negative apocrine carcinoma as a rare cause of a breast lump in a Syrian female: a case report and review of the literature

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