Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis

The adverse impact of Coronavirus disease 2019 (COVID-19) on kidney function has been reported since the global pandemic. The burden of COVID-19 on kidney transplant recipients, however, has not been systematically analyzed. A systematic review and meta-analysis with a random-effect model was conduc...

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Autores principales:	Jia-Jin Chen, George Kuo, Tao Han Lee, Huang-Yu Yang, Hsin Hsu Wu, Kun-Hua Tu, Ya-Chung Tian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	acute kidney injury coronavirus disease 2019 kidney replacement therapy graft loss mortality Medicine R
Acceso en línea:	https://doaj.org/article/4f7778f77fc648728c6c0df66ea105f2
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spelling	oai:doaj.org-article:4f7778f77fc648728c6c0df66ea105f22021-11-11T17:46:42ZIncidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis10.3390/jcm102151622077-0383https://doaj.org/article/4f7778f77fc648728c6c0df66ea105f22021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5162https://doaj.org/toc/2077-0383The adverse impact of Coronavirus disease 2019 (COVID-19) on kidney function has been reported since the global pandemic. The burden of COVID-19 on kidney transplant recipients, however, has not been systematically analyzed. A systematic review and meta-analysis with a random-effect model was conducted to explore the rate of mortality, intensive care unit admission, invasive mechanical ventilation, acute kidney injury, kidney replacement therapy and graft loss in the adult kidney transplant population with COVID-19. Sensitivity analysis, subgroup analysis and meta-regression were also performed. Results: we demonstrated a pooled mortality rate of 21% (95% CI: 19−23%), an intensive care unit admission rate of 26% (95% CI: 22–31%), an invasive ventilation rate among those who required intensive care unit care of 72% (95% CI: 62–81%), an acute kidney injury rate of 44% (95% CI: 39–49%), a kidney replacement therapy rate of 12% (95% CI: 9–15%), and a graft loss rate of 8% (95% CI: 5–15%) in kidney transplant recipients with COVID-19. The meta-regression indicated that advancing age is associated with higher mortality; every increase in age by 10 years was associated with an increased mortality rate of 3.7%. Regional differences in outcome were also detected. Further studies focused on treatments and risk factor identification are needed.Jia-Jin ChenGeorge KuoTao Han LeeHuang-Yu YangHsin Hsu WuKun-Hua TuYa-Chung TianMDPI AGarticleacute kidney injurycoronavirus disease 2019kidney replacement therapygraft lossmortalityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5162, p 5162 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute kidney injury coronavirus disease 2019 kidney replacement therapy graft loss mortality Medicine R
spellingShingle	acute kidney injury coronavirus disease 2019 kidney replacement therapy graft loss mortality Medicine R Jia-Jin Chen George Kuo Tao Han Lee Huang-Yu Yang Hsin Hsu Wu Kun-Hua Tu Ya-Chung Tian Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis
description	The adverse impact of Coronavirus disease 2019 (COVID-19) on kidney function has been reported since the global pandemic. The burden of COVID-19 on kidney transplant recipients, however, has not been systematically analyzed. A systematic review and meta-analysis with a random-effect model was conducted to explore the rate of mortality, intensive care unit admission, invasive mechanical ventilation, acute kidney injury, kidney replacement therapy and graft loss in the adult kidney transplant population with COVID-19. Sensitivity analysis, subgroup analysis and meta-regression were also performed. Results: we demonstrated a pooled mortality rate of 21% (95% CI: 19−23%), an intensive care unit admission rate of 26% (95% CI: 22–31%), an invasive ventilation rate among those who required intensive care unit care of 72% (95% CI: 62–81%), an acute kidney injury rate of 44% (95% CI: 39–49%), a kidney replacement therapy rate of 12% (95% CI: 9–15%), and a graft loss rate of 8% (95% CI: 5–15%) in kidney transplant recipients with COVID-19. The meta-regression indicated that advancing age is associated with higher mortality; every increase in age by 10 years was associated with an increased mortality rate of 3.7%. Regional differences in outcome were also detected. Further studies focused on treatments and risk factor identification are needed.
format	article
author	Jia-Jin Chen George Kuo Tao Han Lee Huang-Yu Yang Hsin Hsu Wu Kun-Hua Tu Ya-Chung Tian
author_facet	Jia-Jin Chen George Kuo Tao Han Lee Huang-Yu Yang Hsin Hsu Wu Kun-Hua Tu Ya-Chung Tian
author_sort	Jia-Jin Chen
title	Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis
title_short	Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis
title_full	Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis
title_fullStr	Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis
title_full_unstemmed	Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis
title_sort	incidence of mortality, acute kidney injury and graft loss in adult kidney transplant recipients with coronavirus disease 2019: systematic review and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f7778f77fc648728c6c0df66ea105f2
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Incidence of Mortality, Acute Kidney Injury and Graft Loss in Adult Kidney Transplant Recipients with Coronavirus Disease 2019: Systematic Review and Meta-Analysis

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