Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers

Masamichi Ishioka, Norio Yasui-Furukori, Norio Sugawara, Hanako Furukori, Shuhei Kudo, Kazuhiko Nakamura Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Objective: The strong association between psychiatric patients who receive antipsychotics and...

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Autores principales:	Ishioka M, Yasui-Furukori N, Sugawara N, Furukori H, Kudo S, Nakamura K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4f7adeda1cbe40bdab0959b13420797a
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spelling	oai:doaj.org-article:4f7adeda1cbe40bdab0959b13420797a2021-12-02T03:24:52ZHyperprolactinemia during antipsychotics treatment increases the level of coagulation markers1178-2021https://doaj.org/article/4f7adeda1cbe40bdab0959b13420797a2015-02-01T00:00:00Zhttp://www.dovepress.com/hyperprolactinemia-during-antipsychotics-treatment-increases-the-level-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Masamichi Ishioka, Norio Yasui-Furukori, Norio Sugawara, Hanako Furukori, Shuhei Kudo, Kazuhiko Nakamura Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Objective: The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE) is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolactin level elevated by antipsychotics and activated markers of activated coagulation.Method: The participants included 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months. Markers of VTE (D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin complex) and serum prolactin concentrations were measured.Results: Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) but not of the thrombin–antithrombin complex level (r=0.117, ns) among men. However, no correlations were found between the VTE markers and prolactin levels among women. These results were confirmed using multiple regression analyses that included demographic factors and antipsychotic dosages. Conclusion: The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE. Keywords: prolactin, antipsychotics, venous thromboembolismIshioka MYasui-Furukori NSugawara NFurukori HKudo SNakamura KDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 477-484 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ishioka M Yasui-Furukori N Sugawara N Furukori H Kudo S Nakamura K Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
description	Masamichi Ishioka, Norio Yasui-Furukori, Norio Sugawara, Hanako Furukori, Shuhei Kudo, Kazuhiko Nakamura Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Objective: The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE) is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolactin level elevated by antipsychotics and activated markers of activated coagulation.Method: The participants included 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months. Markers of VTE (D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin complex) and serum prolactin concentrations were measured.Results: Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) but not of the thrombin–antithrombin complex level (r=0.117, ns) among men. However, no correlations were found between the VTE markers and prolactin levels among women. These results were confirmed using multiple regression analyses that included demographic factors and antipsychotic dosages. Conclusion: The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE. Keywords: prolactin, antipsychotics, venous thromboembolism
format	article
author	Ishioka M Yasui-Furukori N Sugawara N Furukori H Kudo S Nakamura K
author_facet	Ishioka M Yasui-Furukori N Sugawara N Furukori H Kudo S Nakamura K
author_sort	Ishioka M
title	Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
title_short	Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
title_full	Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
title_fullStr	Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
title_full_unstemmed	Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
title_sort	hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/4f7adeda1cbe40bdab0959b13420797a
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Hyperprolactinemia during antipsychotics treatment increases the level of coagulation&nbsp;markers

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Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers