An attenuated Machupo virus with a disrupted L-segment intergenic region protects guinea pigs against lethal Guanarito virus infection
Abstract Machupo virus (MACV) is a New World (NW) arenavirus and causative agent of Bolivian hemorrhagic fever (HF). Here, we identified a variant of MACV strain Carvallo termed Car91 that was attenuated in guinea pigs. Infection of guinea pigs with an earlier passage of Carvallo, termed Car68, resu...
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Autores principales: | Joseph W. Golden, Brett Beitzel, Jason T. Ladner, Eric M. Mucker, Steven A. Kwilas, Gustavo Palacios, Jay W. Hooper |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/4f7b5bc0b3ea44f68846a16a888e462d |
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