Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability

Yujin Jo,1 Yong Tae Kim,2 Hoonsung Cho,2 Min-Kyung Ji,3 Jaeyeong Heo,2,3 Hyun-Pil Lim1 1Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Korea; 2Department of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Korea; 3Optoelectroni...

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Autores principales:	Jo Y, Kim YT, Cho H, Ji MK, Heo J, Lim HP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	atomic layer deposition ald surface treatment titanium zirconia implant Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4f7b85d6d2954f728a3be103a3532517
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spelling	oai:doaj.org-article:4f7b85d6d2954f728a3be103a35325172021-12-02T18:17:07ZAtomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability1178-2013https://doaj.org/article/4f7b85d6d2954f728a3be103a35325172021-02-01T00:00:00Zhttps://www.dovepress.com/atomic-layer-deposition-of-zro2-on-titanium-inhibits-bacterial-adhesio-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yujin Jo,1 Yong Tae Kim,2 Hoonsung Cho,2 Min-Kyung Ji,3 Jaeyeong Heo,2,3 Hyun-Pil Lim1 1Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Korea; 2Department of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Korea; 3Optoelectronics Convergence Research Center, Chonnam National University, Gwangju, 61186, Republic of KoreaCorrespondence: Hyun-Pil LimDepartment of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, 61186, KoreaTel +82-10-2645-7528Fax +82-62-530-5577Email mcnihil@jnu.ac.krJaeyeong HeoDepartment of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, KoreaTel +82-62-530-1716Fax +82-62-530-1699Email jheo@jnu.ac.krPurpose: The study was intended to create a uniform zirconia layer even on the surface of complex structures via atomic layer deposition (ALD). The impact of crystalline zirconia deposited by ALD on bacterial adhesion and osteoblast viability was assessed via surface treatment of dental implants.Methods: Amorphous zirconia was deposited using an atomic layer deposition reactor (Atomic Classic, CN1, Hwaseong, Korea) on titanium discs. Heating the samples at 400°C resulted in crystallization. Samples were divided into three groups: the control group, the group carrying amorphous ALD-zirconia (Z group), and the heat-treated group following zirconia ALD deposition (ZH group).The surface of each sample was analyzed, followed by the assessment of adhesion of Streptococcus mutans and Porphyromonas gingivalis, and viability and differentiation of MC3T3-E1 cells.Results: The adhesion of S. mutans and P. gingivalis was significantly reduced in the Z and ZH groups compared with the control group (P < 0.05). The viability of MC3T3-E1 cells was significantly increased in the ZH group compared with the control group (P < 0.001), while no significant differences were observed in the Z group (P > 0.05). Differentiation of MC3T3-E1 cells showed a marginally significant increase in the ZH group compared with the control group (P < 0.1), while no significant differences were found in the Z group (P > 0.1).Conclusion: Compared with the pure titanium group, the groups that were coated with zirconia via ALD showed a decreased adhesion of S. mutans during the early stages of biofilm formation and P. gingivalis adhesion inducing peri-implantitis, and an increase in MC3T3-E1 cell viability and differentiation. The findings indicate the possibility of treating the implant surface to reduce peri-implantitis and improve osseointegration.Keywords: atomic layer deposition, ALD, surface treatment, titanium, zirconia, implantJo YKim YTCho HJi MKHeo JLim HPDove Medical Pressarticleatomic layer depositionaldsurface treatmenttitaniumzirconiaimplantMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 1509-1523 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atomic layer deposition ald surface treatment titanium zirconia implant Medicine (General) R5-920
spellingShingle	atomic layer deposition ald surface treatment titanium zirconia implant Medicine (General) R5-920 Jo Y Kim YT Cho H Ji MK Heo J Lim HP Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability
description	Yujin Jo,1 Yong Tae Kim,2 Hoonsung Cho,2 Min-Kyung Ji,3 Jaeyeong Heo,2,3 Hyun-Pil Lim1 1Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Korea; 2Department of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Korea; 3Optoelectronics Convergence Research Center, Chonnam National University, Gwangju, 61186, Republic of KoreaCorrespondence: Hyun-Pil LimDepartment of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, 61186, KoreaTel +82-10-2645-7528Fax +82-62-530-5577Email mcnihil@jnu.ac.krJaeyeong HeoDepartment of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, KoreaTel +82-62-530-1716Fax +82-62-530-1699Email jheo@jnu.ac.krPurpose: The study was intended to create a uniform zirconia layer even on the surface of complex structures via atomic layer deposition (ALD). The impact of crystalline zirconia deposited by ALD on bacterial adhesion and osteoblast viability was assessed via surface treatment of dental implants.Methods: Amorphous zirconia was deposited using an atomic layer deposition reactor (Atomic Classic, CN1, Hwaseong, Korea) on titanium discs. Heating the samples at 400°C resulted in crystallization. Samples were divided into three groups: the control group, the group carrying amorphous ALD-zirconia (Z group), and the heat-treated group following zirconia ALD deposition (ZH group).The surface of each sample was analyzed, followed by the assessment of adhesion of Streptococcus mutans and Porphyromonas gingivalis, and viability and differentiation of MC3T3-E1 cells.Results: The adhesion of S. mutans and P. gingivalis was significantly reduced in the Z and ZH groups compared with the control group (P < 0.05). The viability of MC3T3-E1 cells was significantly increased in the ZH group compared with the control group (P < 0.001), while no significant differences were observed in the Z group (P > 0.05). Differentiation of MC3T3-E1 cells showed a marginally significant increase in the ZH group compared with the control group (P < 0.1), while no significant differences were found in the Z group (P > 0.1).Conclusion: Compared with the pure titanium group, the groups that were coated with zirconia via ALD showed a decreased adhesion of S. mutans during the early stages of biofilm formation and P. gingivalis adhesion inducing peri-implantitis, and an increase in MC3T3-E1 cell viability and differentiation. The findings indicate the possibility of treating the implant surface to reduce peri-implantitis and improve osseointegration.Keywords: atomic layer deposition, ALD, surface treatment, titanium, zirconia, implant
format	article
author	Jo Y Kim YT Cho H Ji MK Heo J Lim HP
author_facet	Jo Y Kim YT Cho H Ji MK Heo J Lim HP
author_sort	Jo Y
title	Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability
title_short	Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability
title_full	Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability
title_fullStr	Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability
title_full_unstemmed	Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability
title_sort	atomic layer deposition of zro2 on titanium inhibits bacterial adhesion and enhances osteoblast viability
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4f7b85d6d2954f728a3be103a3532517
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Atomic Layer Deposition of ZrO2 on Titanium Inhibits Bacterial Adhesion and Enhances Osteoblast Viability

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