Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance.

Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance.

Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides. Specifically, ATM phosphorylates and activates de...

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Autores principales: Yuri L Bunimovich, Evan Nair-Gill, Mireille Riedinger, Melissa N McCracken, Donghui Cheng, Jami McLaughlin, Caius G Radu, Owen N Witte
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/4f7f2fb282054ae599f251086f332978
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