COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION

Objective: To determine the analgesic efficacy of lignocaine combined with dexamethasone and lignocaine infusion in patients with advance cancer disease. Study Design: Randomized controlled trial. Place and Duration of Study: Pain centre Combined Military Hospital Rawalpindi, from Apr 2016 to Nov...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Syed Majid Waseem, Amjad Iqbal
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4f82fe21c20744aeb657c99d1f0314ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f82fe21c20744aeb657c99d1f0314ba
record_format	dspace
spelling	oai:doaj.org-article:4f82fe21c20744aeb657c99d1f0314ba2021-12-01T03:11:17ZCOMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION0030-96482411-8842https://doaj.org/article/4f82fe21c20744aeb657c99d1f0314ba2018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2265/1962https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the analgesic efficacy of lignocaine combined with dexamethasone and lignocaine infusion in patients with advance cancer disease. Study Design: Randomized controlled trial. Place and Duration of Study: Pain centre Combined Military Hospital Rawalpindi, from Apr 2016 to Nov 2016. Material and Methods: Total 122 patients, 61 in each group, fulfilling the inclusion criteria were included in this study after approval of the ethical committee. The technique used was non probability consecutive sampling. Two groups were made; group-A received Lignocaine 2mg/kg and group-B Lignocaine 2mg/kg with dexamethasone 0.15mg/kg in continuous infusion over 30 minutes. Both regimen were administered twice weekly for a period of 12 weeks as an outdoor procedure. Numerical rating scale used to measure severity of pain. Baseline and outcome parameters of all patients’ i.e. severity of persistent and breakthrough pain and percentage relief of pain were recorded and compared at 12 weeks. Mean ± standard deviations were calculated for quantitative variables, while qualitative variables presented in frequency and percentages. Chi-square test used for qualitative variables while Independent sample t-test used to compare means. A p-value <0.05 was considered statistically significant. Results: When results of group-B compared with group-A, there was a significant reduction in severity of persistent pain from 5.68 ± 2.08 to 2.83 ± 1.01 (p-value <0.05), breakthrough pain from 5.90 ± 2.07 to 3.06 ± 1.09 (p-value <0.05). The percentage relief of pain was 45.08 ± 15.01 (%) when compared to baseline i.e. 23.35 ± 8.55 (%) (p-value <0.05). Conclusion: Lignocaine with dexamethasone has shown to be effective in reducing complex cancer related pain and disability when compared with Lignocaine alone.Syed Majid WaseemAmjad IqbalArmy Medical College RawalpindiarticleMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1111-1115 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Medicine (General) R5-920
spellingShingle	Medicine R Medicine (General) R5-920 Syed Majid Waseem Amjad Iqbal COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION
description	Objective: To determine the analgesic efficacy of lignocaine combined with dexamethasone and lignocaine infusion in patients with advance cancer disease. Study Design: Randomized controlled trial. Place and Duration of Study: Pain centre Combined Military Hospital Rawalpindi, from Apr 2016 to Nov 2016. Material and Methods: Total 122 patients, 61 in each group, fulfilling the inclusion criteria were included in this study after approval of the ethical committee. The technique used was non probability consecutive sampling. Two groups were made; group-A received Lignocaine 2mg/kg and group-B Lignocaine 2mg/kg with dexamethasone 0.15mg/kg in continuous infusion over 30 minutes. Both regimen were administered twice weekly for a period of 12 weeks as an outdoor procedure. Numerical rating scale used to measure severity of pain. Baseline and outcome parameters of all patients’ i.e. severity of persistent and breakthrough pain and percentage relief of pain were recorded and compared at 12 weeks. Mean ± standard deviations were calculated for quantitative variables, while qualitative variables presented in frequency and percentages. Chi-square test used for qualitative variables while Independent sample t-test used to compare means. A p-value <0.05 was considered statistically significant. Results: When results of group-B compared with group-A, there was a significant reduction in severity of persistent pain from 5.68 ± 2.08 to 2.83 ± 1.01 (p-value <0.05), breakthrough pain from 5.90 ± 2.07 to 3.06 ± 1.09 (p-value <0.05). The percentage relief of pain was 45.08 ± 15.01 (%) when compared to baseline i.e. 23.35 ± 8.55 (%) (p-value <0.05). Conclusion: Lignocaine with dexamethasone has shown to be effective in reducing complex cancer related pain and disability when compared with Lignocaine alone.
format	article
author	Syed Majid Waseem Amjad Iqbal
author_facet	Syed Majid Waseem Amjad Iqbal
author_sort	Syed Majid Waseem
title	COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION
title_short	COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION
title_full	COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION
title_fullStr	COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION
title_full_unstemmed	COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION
title_sort	comparison of analgesic efficacy of systemic lignocaine combined with dexamethasone and lignocaine infusion
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/4f82fe21c20744aeb657c99d1f0314ba
work_keys_str_mv	AT syedmajidwaseem comparisonofanalgesicefficacyofsystemiclignocainecombinedwithdexamethasoneandlignocaineinfusion AT amjadiqbal comparisonofanalgesicefficacyofsystemiclignocainecombinedwithdexamethasoneandlignocaineinfusion
_version_	1718405900942704640

COMPARISON OF ANALGESIC EFFICACY OF SYSTEMIC LIGNOCAINE COMBINED WITH DEXAMETHASONE AND LIGNOCAINE INFUSION

Ejemplares similares