Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection

(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 an...

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Autores principales:	Cristina Tudoran, Mariana Tudoran, Voichita Elena Lazureanu, Adelina Raluca Marinescu, Talida Georgiana Cut, Cristian Oancea, Silvius Alexandru Pescariu, Gheorghe Nicusor Pop
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pulmonary hypertension right ventricular dysfunction transthoracic echocardiography post-COVID-19 syndrome long-term evolution Medicine R
Acceso en línea:	https://doaj.org/article/4f8423a4de4740b88e23f6882b4e317e
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spelling	oai:doaj.org-article:4f8423a4de4740b88e23f6882b4e317e2021-11-25T18:01:10ZFactors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection10.3390/jcm102252722077-0383https://doaj.org/article/4f8423a4de4740b88e23f6882b4e317e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5272https://doaj.org/toc/2077-0383(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 and 6 months after the acute COVID-19 infection and investigate if there are differences regarding its evolution between the patients from the first three waves of this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), the 3 and 6 months’ evolution of the echocardiographically estimated systolic pulmonary artery pressures (esPAP) in 116 patients already diagnosed with PH or BPH due to COVID-19 during the first three subsequent waves of COVID-19. (3) Results: We documented a gradual, statistically significant reduction in esPAP values, but also an improvement of the parameters characterizing RVD after 3 and 6 months (<i>p</i> < 0.001). This evolution was somewhat different between subjects infected with different viral strains and was related to the initial severity of the pulmonary injury and PH (adjusted R<sup>2</sup> = 0.722, <i>p</i> < 0.001). (4) Conclusions: PH and RVD alleviate gradually during the recovery after COVID-19, but in some cases, they persist, suggesting the activation of pathophysiological mechanisms responsible for the self-propagation of PH.Cristina TudoranMariana TudoranVoichita Elena LazureanuAdelina Raluca MarinescuTalida Georgiana CutCristian OanceaSilvius Alexandru PescariuGheorghe Nicusor PopMDPI AGarticlepulmonary hypertensionright ventricular dysfunctiontransthoracic echocardiographypost-COVID-19 syndromelong-term evolutionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5272, p 5272 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulmonary hypertension right ventricular dysfunction transthoracic echocardiography post-COVID-19 syndrome long-term evolution Medicine R
spellingShingle	pulmonary hypertension right ventricular dysfunction transthoracic echocardiography post-COVID-19 syndrome long-term evolution Medicine R Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Talida Georgiana Cut Cristian Oancea Silvius Alexandru Pescariu Gheorghe Nicusor Pop Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
description	(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 and 6 months after the acute COVID-19 infection and investigate if there are differences regarding its evolution between the patients from the first three waves of this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), the 3 and 6 months’ evolution of the echocardiographically estimated systolic pulmonary artery pressures (esPAP) in 116 patients already diagnosed with PH or BPH due to COVID-19 during the first three subsequent waves of COVID-19. (3) Results: We documented a gradual, statistically significant reduction in esPAP values, but also an improvement of the parameters characterizing RVD after 3 and 6 months (<i>p</i> < 0.001). This evolution was somewhat different between subjects infected with different viral strains and was related to the initial severity of the pulmonary injury and PH (adjusted R<sup>2</sup> = 0.722, <i>p</i> < 0.001). (4) Conclusions: PH and RVD alleviate gradually during the recovery after COVID-19, but in some cases, they persist, suggesting the activation of pathophysiological mechanisms responsible for the self-propagation of PH.
format	article
author	Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Talida Georgiana Cut Cristian Oancea Silvius Alexandru Pescariu Gheorghe Nicusor Pop
author_facet	Cristina Tudoran Mariana Tudoran Voichita Elena Lazureanu Adelina Raluca Marinescu Talida Georgiana Cut Cristian Oancea Silvius Alexandru Pescariu Gheorghe Nicusor Pop
author_sort	Cristina Tudoran
title	Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
title_short	Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
title_full	Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
title_fullStr	Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
title_full_unstemmed	Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection
title_sort	factors influencing the evolution of pulmonary hypertension in previously healthy subjects recovering from a sars-cov-2 infection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f8423a4de4740b88e23f6882b4e317e
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Factors Influencing the Evolution of Pulmonary Hypertension in Previously Healthy Subjects Recovering from a SARS-CoV-2 Infection

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