Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height

Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana-Belen Ariza-Jimenez, Isabel Leiva Gea, Maria Jose Martinez-Aedo Ollero, Juan Pedro Lopez-Siguero
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	growth hormone treatment growth hormone deficiency idiopathic short stature final height Medicine R
Acceso en línea:	https://doaj.org/article/4f881e7366af45fcbb92a7450b616b30
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4f881e7366af45fcbb92a7450b616b30
record_format	dspace
spelling	oai:doaj.org-article:4f881e7366af45fcbb92a7450b616b302021-11-11T17:37:08ZIsolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height10.3390/jcm102149882077-0383https://doaj.org/article/4f881e7366af45fcbb92a7450b616b302021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4988https://doaj.org/toc/2077-0383Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects. Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were −1.52 SD, −1.31 SD, and −2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD. Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups.Ana-Belen Ariza-JimenezIsabel Leiva GeaMaria Jose Martinez-Aedo OlleroJuan Pedro Lopez-SigueroMDPI AGarticlegrowth hormone treatmentgrowth hormone deficiencyidiopathic short staturefinal heightMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4988, p 4988 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth hormone treatment growth hormone deficiency idiopathic short stature final height Medicine R
spellingShingle	growth hormone treatment growth hormone deficiency idiopathic short stature final height Medicine R Ana-Belen Ariza-Jimenez Isabel Leiva Gea Maria Jose Martinez-Aedo Ollero Juan Pedro Lopez-Siguero Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
description	Introduction: Treatment with growth hormone (GH) is not approved for idiopathic short stature (ISS) in Europe. Objectives: To compare the growth of children treated with isolated GH deficiency (IGHD) vs. ISS-treated and untreated children. Methods: A retrospective descriptive study of patients treated in the last 14 years for IGHD (Group A), in comparison with ISS-treated (Group B) and untreated (Group C) subjects. Results: Group A had 67 males, who showed a height gain of 1.24 SD. Group B had 30 boys, who showed a height gain of 1.47 SD. Group C had 42 boys, who showed an improvement of 0.37 SD. The final heights were −1.52 SD, −1.31 SD, and −2.03 SD, respectively. Group A and C did not reach their target heights (with differences of 0.27 SD and 0.59 SD, respectively). Group B surpassed their target height by 0.29 SD. Conclusions: The final heights of the IGHD and treated ISS are similar. Treated groups were taller than untreated groups.
format	article
author	Ana-Belen Ariza-Jimenez Isabel Leiva Gea Maria Jose Martinez-Aedo Ollero Juan Pedro Lopez-Siguero
author_facet	Ana-Belen Ariza-Jimenez Isabel Leiva Gea Maria Jose Martinez-Aedo Ollero Juan Pedro Lopez-Siguero
author_sort	Ana-Belen Ariza-Jimenez
title	Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
title_short	Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
title_full	Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
title_fullStr	Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
title_full_unstemmed	Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height
title_sort	isolated growth hormone deficiency and idiopathic short stature: comparative efficiency after growth hormone treatment up to adult height
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f881e7366af45fcbb92a7450b616b30
work_keys_str_mv	AT anabelenarizajimenez isolatedgrowthhormonedeficiencyandidiopathicshortstaturecomparativeefficiencyaftergrowthhormonetreatmentuptoadultheight AT isabelleivagea isolatedgrowthhormonedeficiencyandidiopathicshortstaturecomparativeefficiencyaftergrowthhormonetreatmentuptoadultheight AT mariajosemartinezaedoollero isolatedgrowthhormonedeficiencyandidiopathicshortstaturecomparativeefficiencyaftergrowthhormonetreatmentuptoadultheight AT juanpedrolopezsiguero isolatedgrowthhormonedeficiencyandidiopathicshortstaturecomparativeefficiencyaftergrowthhormonetreatmentuptoadultheight
_version_	1718432062476648448

Isolated Growth Hormone Deficiency and Idiopathic Short Stature: Comparative Efficiency after Growth Hormone Treatment up to Adult Height

Ejemplares similares