Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model

Marco Mura,1– 3 Wendy Martin,4 K Keven Williams,4 Dina Joy K Abulon5 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Ophthalmology, University of Illinois, Chicago, IL, USA; 3Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabi...

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Autores principales:	Mura M, Martin W, Williams KK, Abulon DJK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	3d digital display systems ngenuity vitrectomy. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/4f8840048ff04aeeb71a53d8428a8d39
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spelling	oai:doaj.org-article:4f8840048ff04aeeb71a53d8428a8d392021-11-21T19:08:51ZComparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model1177-5483https://doaj.org/article/4f8840048ff04aeeb71a53d8428a8d392021-11-01T00:00:00Zhttps://www.dovepress.com/comparison-of-3d-digitally-assisted-visualization-system-with-current--peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Marco Mura,1– 3 Wendy Martin,4 K Keven Williams,4 Dina Joy K Abulon5 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Ophthalmology, University of Illinois, Chicago, IL, USA; 3Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 4Preclinical Development, Alcon Vision LLC, Fort Worth, TX, USA; 5Global Medical Affairs, Alcon Vision LLC, Irvine, CA, USACorrespondence: Marco MuraDepartment of Translational Medicine, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, ItalyTel +390532455845Fax +390532207351Email marco.mura@unife.itPurpose: Novel 3D digital display systems, such as NGENUITY 3D digitally assisted visualization system (DAVS), can provide enhanced illumination, depth of field, and digital filtering. This study compared vitreous removal using NGENUITY 3D DAVS with a standard surgical microscope.Methods: This was an in vivo, 2-arm laboratory study in 15 Yorkshire pig eyes. The LuxOR LX3 microscope with NGENUITY 3D DAVS (arm 1) and the LuxOR LX3 microscope alone (arm 2) were used with 5× optical magnification and Oculus BIOM 200 mm optics. Standard core and peripheral vitrectomy without scleral depression was performed using the CONSTELLATION Vision System. Residual vitreous weight was assessed in enucleated eyes by a masked observer. Axial length and vitreous weight of contralateral eyes were compared from an additional 14 Yorkshire pigs to confirm that eyes from a single animal were essentially identical.Results: After vitrectomy, mean ± SD residual vitreous was significantly smaller with NGENUITY versus standard microscope (0.143 ± 0.146 versus 0.580 ± 0.269 g, respectively; P < 0.0001). Based on a mean initial vitreous weight of 2.5 g, as determined by assessment in contralateral eyes from an additional 14 Yorkshire pigs, the mean percentage vitreous removal was 94% ± 6% versus 77% ± 11%, respectively. Further, vitreous weight and axial length for contralateral eyes from any single animal in these additional 14 animals were essentially identical, as mean differences were 0.046 ± 0.035 g and 0.11 ± 0.08 mm, respectively.Conclusion: Vitrectomy with NGENUITY 3D DAVS resulted in significantly less residual vitreous in pig eyes compared with standard microscopy. NGENUITY may improve vitreous removal during vitreoretinal surgery by enhancing visualization.Keywords: 3D digital display systems, NGENUITY, vitrectomyMura MMartin WWilliams KKAbulon DJKDove Medical Pressarticle3d digital display systemsngenuityvitrectomy.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 4499-4505 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3d digital display systems ngenuity vitrectomy. Ophthalmology RE1-994
spellingShingle	3d digital display systems ngenuity vitrectomy. Ophthalmology RE1-994 Mura M Martin W Williams KK Abulon DJK Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model
description	Marco Mura,1– 3 Wendy Martin,4 K Keven Williams,4 Dina Joy K Abulon5 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Ophthalmology, University of Illinois, Chicago, IL, USA; 3Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 4Preclinical Development, Alcon Vision LLC, Fort Worth, TX, USA; 5Global Medical Affairs, Alcon Vision LLC, Irvine, CA, USACorrespondence: Marco MuraDepartment of Translational Medicine, University of Ferrara, Via Luigi Borsari 46, Ferrara, 44121, ItalyTel +390532455845Fax +390532207351Email marco.mura@unife.itPurpose: Novel 3D digital display systems, such as NGENUITY 3D digitally assisted visualization system (DAVS), can provide enhanced illumination, depth of field, and digital filtering. This study compared vitreous removal using NGENUITY 3D DAVS with a standard surgical microscope.Methods: This was an in vivo, 2-arm laboratory study in 15 Yorkshire pig eyes. The LuxOR LX3 microscope with NGENUITY 3D DAVS (arm 1) and the LuxOR LX3 microscope alone (arm 2) were used with 5× optical magnification and Oculus BIOM 200 mm optics. Standard core and peripheral vitrectomy without scleral depression was performed using the CONSTELLATION Vision System. Residual vitreous weight was assessed in enucleated eyes by a masked observer. Axial length and vitreous weight of contralateral eyes were compared from an additional 14 Yorkshire pigs to confirm that eyes from a single animal were essentially identical.Results: After vitrectomy, mean ± SD residual vitreous was significantly smaller with NGENUITY versus standard microscope (0.143 ± 0.146 versus 0.580 ± 0.269 g, respectively; P < 0.0001). Based on a mean initial vitreous weight of 2.5 g, as determined by assessment in contralateral eyes from an additional 14 Yorkshire pigs, the mean percentage vitreous removal was 94% ± 6% versus 77% ± 11%, respectively. Further, vitreous weight and axial length for contralateral eyes from any single animal in these additional 14 animals were essentially identical, as mean differences were 0.046 ± 0.035 g and 0.11 ± 0.08 mm, respectively.Conclusion: Vitrectomy with NGENUITY 3D DAVS resulted in significantly less residual vitreous in pig eyes compared with standard microscopy. NGENUITY may improve vitreous removal during vitreoretinal surgery by enhancing visualization.Keywords: 3D digital display systems, NGENUITY, vitrectomy
format	article
author	Mura M Martin W Williams KK Abulon DJK
author_facet	Mura M Martin W Williams KK Abulon DJK
author_sort	Mura M
title	Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model
title_short	Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model
title_full	Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model
title_fullStr	Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model
title_full_unstemmed	Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model
title_sort	comparison of 3d digitally assisted visualization system with current standard visualization for the removal of vitreous in a preclinical model
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4f8840048ff04aeeb71a53d8428a8d39
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Comparison of 3D Digitally Assisted Visualization System with Current Standard Visualization for the Removal of Vitreous in a Preclinical Model

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