Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field

Abstract In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-s...

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Autores principales:	Maxime Yon, Vincent Sarou-Kanian, Ulrich Scheler, Jean-Michel Bouler, Bruno Bujoli, Dominique Massiot, Franck Fayon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f8d5a5b1f904cecaa26f7c147a2b0c1
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spelling	oai:doaj.org-article:4f8d5a5b1f904cecaa26f7c147a2b0c12021-12-02T11:51:11ZSolid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field10.1038/s41598-017-08458-02045-2322https://doaj.org/article/4f8d5a5b1f904cecaa26f7c147a2b0c12017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08458-0https://doaj.org/toc/2045-2322Abstract In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-selected images of rigid tissues and related biomaterials at very high magnetic field, with greatly improved signal to noise ratio and spatial resolution when compared to static conditions. Cross-polarization is employed to enhance contrast and to further depict spatially localized chemical variations in reduced experimental time. In these materials, very high magnetic field and moderate MAS spinning rate directly provide high spectral resolution and enable the use of frequency selective excitation schemes for chemically selective imaging. These new possibilities are exemplified with experiments probing selectively the 3D spatial distribution of apatitic hydroxyl protons inside a mouse tooth with attached jaw bone with a nominal isotropic resolution nearing 100 µm.Maxime YonVincent Sarou-KanianUlrich SchelerJean-Michel BoulerBruno BujoliDominique MassiotFranck FayonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maxime Yon Vincent Sarou-Kanian Ulrich Scheler Jean-Michel Bouler Bruno Bujoli Dominique Massiot Franck Fayon Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
description	Abstract In this work, we show that it is possible to overcome the limitations of solid-state MRI for rigid tissues due to large line broadening and short dephasing times by combining Magic Angle Spinning (MAS) with rotating pulsed field gradients. This allows recording ex vivo 31P 3D and 2D slice-selected images of rigid tissues and related biomaterials at very high magnetic field, with greatly improved signal to noise ratio and spatial resolution when compared to static conditions. Cross-polarization is employed to enhance contrast and to further depict spatially localized chemical variations in reduced experimental time. In these materials, very high magnetic field and moderate MAS spinning rate directly provide high spectral resolution and enable the use of frequency selective excitation schemes for chemically selective imaging. These new possibilities are exemplified with experiments probing selectively the 3D spatial distribution of apatitic hydroxyl protons inside a mouse tooth with attached jaw bone with a nominal isotropic resolution nearing 100 µm.
format	article
author	Maxime Yon Vincent Sarou-Kanian Ulrich Scheler Jean-Michel Bouler Bruno Bujoli Dominique Massiot Franck Fayon
author_facet	Maxime Yon Vincent Sarou-Kanian Ulrich Scheler Jean-Michel Bouler Bruno Bujoli Dominique Massiot Franck Fayon
author_sort	Maxime Yon
title	Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
title_short	Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
title_full	Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
title_fullStr	Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
title_full_unstemmed	Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
title_sort	solid-state 31p and 1h chemical mr micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4f8d5a5b1f904cecaa26f7c147a2b0c1
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Solid-state 31P and 1H chemical MR micro-imaging of hard tissues and biomaterials with magic angle spinning at very high magnetic field

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