Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss

Abstract Background Measurement of serum concentrations of insulin‐like growth factor (IGF)‐1 is used to diagnose acromegaly in cats. Hypothesis Changes of body weight do not affect serum concentrations of IGF‐1 in cats. Animals Ten healthy purpose‐bred cats. Methods Prospective study. In lean cats,...

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Autores principales:	Eric Zini, Elena Salesov, Anke Willing, Carlo Palizzotto, Thomas A. Lutz, Claudia E. Reusch
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	acromegaly diabetes mellitus feline obesity Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/4f9086e75aa149f5bfbfb1b3b50aec7b
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spelling	oai:doaj.org-article:4f9086e75aa149f5bfbfb1b3b50aec7b2021-11-30T17:01:03ZSerum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss1939-16760891-664010.1111/jvim.16119https://doaj.org/article/4f9086e75aa149f5bfbfb1b3b50aec7b2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16119https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Measurement of serum concentrations of insulin‐like growth factor (IGF)‐1 is used to diagnose acromegaly in cats. Hypothesis Changes of body weight do not affect serum concentrations of IGF‐1 in cats. Animals Ten healthy purpose‐bred cats. Methods Prospective study. In lean cats, food availability was stepwise increased during the first week and given ad libitum for a total of 40 weeks to increase their body weight. From week 41 to week 60, food access was limited to reach a weight loss of 1% to 2% each week. Measurement of IGF‐1 was performed at week 0, 16, 40, and 60. Insulin‐like growth factor‐1 was measured by radioimmunoassay. Body weight and IGF‐1 were compared among the 4 time points. Results Body weight increased by 44% from week 0 (4.5 ± 0.4 kg) to week 40 (6.5 ± 1.2 kg) (P < .001) and decreased by 25% from week 40 to week 60 (4.9 ± 0.7 kg) (P < .001). Serum IGF‐1 concentrations did not differ during the study period (week 0, 16, 40, 60: 500 ± 188, 479 ± 247, 470 ± 184, 435 ± 154 ng/mL, respectively; P = .38). Correlations with body weight were not observed. Conclusions and Clinical Importance Insulin‐like growth factor‐1 might not be influenced by changes of body weight in healthy cats, possibly suggesting that the latter is unimportant when interpreting IGF‐1 results in this species.Eric ZiniElena SalesovAnke WillingCarlo PalizzottoThomas A. LutzClaudia E. ReuschWileyarticleacromegalydiabetes mellitusfelineobesityVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1274-1278 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acromegaly diabetes mellitus feline obesity Veterinary medicine SF600-1100
spellingShingle	acromegaly diabetes mellitus feline obesity Veterinary medicine SF600-1100 Eric Zini Elena Salesov Anke Willing Carlo Palizzotto Thomas A. Lutz Claudia E. Reusch Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
description	Abstract Background Measurement of serum concentrations of insulin‐like growth factor (IGF)‐1 is used to diagnose acromegaly in cats. Hypothesis Changes of body weight do not affect serum concentrations of IGF‐1 in cats. Animals Ten healthy purpose‐bred cats. Methods Prospective study. In lean cats, food availability was stepwise increased during the first week and given ad libitum for a total of 40 weeks to increase their body weight. From week 41 to week 60, food access was limited to reach a weight loss of 1% to 2% each week. Measurement of IGF‐1 was performed at week 0, 16, 40, and 60. Insulin‐like growth factor‐1 was measured by radioimmunoassay. Body weight and IGF‐1 were compared among the 4 time points. Results Body weight increased by 44% from week 0 (4.5 ± 0.4 kg) to week 40 (6.5 ± 1.2 kg) (P < .001) and decreased by 25% from week 40 to week 60 (4.9 ± 0.7 kg) (P < .001). Serum IGF‐1 concentrations did not differ during the study period (week 0, 16, 40, 60: 500 ± 188, 479 ± 247, 470 ± 184, 435 ± 154 ng/mL, respectively; P = .38). Correlations with body weight were not observed. Conclusions and Clinical Importance Insulin‐like growth factor‐1 might not be influenced by changes of body weight in healthy cats, possibly suggesting that the latter is unimportant when interpreting IGF‐1 results in this species.
format	article
author	Eric Zini Elena Salesov Anke Willing Carlo Palizzotto Thomas A. Lutz Claudia E. Reusch
author_facet	Eric Zini Elena Salesov Anke Willing Carlo Palizzotto Thomas A. Lutz Claudia E. Reusch
author_sort	Eric Zini
title	Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
title_short	Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
title_full	Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
title_fullStr	Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
title_full_unstemmed	Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
title_sort	serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/4f9086e75aa149f5bfbfb1b3b50aec7b
work_keys_str_mv	AT ericzini seruminsulinlikegrowthfactor1concentrationsinhealthycatsbeforeandafterweightgainandweightloss AT elenasalesov seruminsulinlikegrowthfactor1concentrationsinhealthycatsbeforeandafterweightgainandweightloss AT ankewilling seruminsulinlikegrowthfactor1concentrationsinhealthycatsbeforeandafterweightgainandweightloss AT carlopalizzotto seruminsulinlikegrowthfactor1concentrationsinhealthycatsbeforeandafterweightgainandweightloss AT thomasalutz seruminsulinlikegrowthfactor1concentrationsinhealthycatsbeforeandafterweightgainandweightloss AT claudiaereusch seruminsulinlikegrowthfactor1concentrationsinhealthycatsbeforeandafterweightgainandweightloss
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Serum insulin‐like growth factor‐1 concentrations in healthy cats before and after weight gain and weight loss

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