Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis

Abstract The characteristics of Mycoplasma pneumonia (M. pneumoniae)-associated bronchiolitis obliterans (BO) are not well known. We retrospectively reviewed 17 patients with M. pneumoniae–associated BO. All patients had M. pneumoniae–associated acute bronchiolitis prior to the development of BO. In...

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Autores principales:	Chengsong Zhao, Jinrong Liu, Haiming Yang, Li Xiang, Shunying Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f94283f7ac843f0974472fc6772a349
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spelling	oai:doaj.org-article:4f94283f7ac843f0974472fc6772a3492021-12-02T15:04:59ZMycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis10.1038/s41598-017-08861-72045-2322https://doaj.org/article/4f94283f7ac843f0974472fc6772a3492017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08861-7https://doaj.org/toc/2045-2322Abstract The characteristics of Mycoplasma pneumonia (M. pneumoniae)-associated bronchiolitis obliterans (BO) are not well known. We retrospectively reviewed 17 patients with M. pneumoniae–associated BO. All patients had M. pneumoniae–associated acute bronchiolitis prior to the development of BO. In the acute bronchiolitis stage, all patients had fever and cough; six patients also had wheezing and dyspnoea. BO was diagnosed approximately 1.5–8 months later based on clinical manifestations and chest high-resolution computed tomography (HRCT) findings. All patients presented with wheezing and/or dyspnoea at the time of diagnosis of BO. HRCT findings included mosaic attenuation, pronounced air trapping, central bronchiectasis and emphysema, according to disease severity. Lung function tests revealed mild to severe airway obstruction. Fourteen of 17 patients had a greater than 12% increase in forced expiratory volume in 1 second values after taking salbutamol. All patients had positive allergy test results and family or personal history of atopic disease. Four patients had a history of asthma before M. pneumonia bronchiolitis. Asthma was diagnosed before, at the time of or after the diagnosis of BO in 11 cases. M. pneumoniae–associated BO may therefore develop following M. pneumonia bronchiolitis and overlap with asthma.Chengsong ZhaoJinrong LiuHaiming YangLi XiangShunying ZhaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chengsong Zhao Jinrong Liu Haiming Yang Li Xiang Shunying Zhao Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis
description	Abstract The characteristics of Mycoplasma pneumonia (M. pneumoniae)-associated bronchiolitis obliterans (BO) are not well known. We retrospectively reviewed 17 patients with M. pneumoniae–associated BO. All patients had M. pneumoniae–associated acute bronchiolitis prior to the development of BO. In the acute bronchiolitis stage, all patients had fever and cough; six patients also had wheezing and dyspnoea. BO was diagnosed approximately 1.5–8 months later based on clinical manifestations and chest high-resolution computed tomography (HRCT) findings. All patients presented with wheezing and/or dyspnoea at the time of diagnosis of BO. HRCT findings included mosaic attenuation, pronounced air trapping, central bronchiectasis and emphysema, according to disease severity. Lung function tests revealed mild to severe airway obstruction. Fourteen of 17 patients had a greater than 12% increase in forced expiratory volume in 1 second values after taking salbutamol. All patients had positive allergy test results and family or personal history of atopic disease. Four patients had a history of asthma before M. pneumonia bronchiolitis. Asthma was diagnosed before, at the time of or after the diagnosis of BO in 11 cases. M. pneumoniae–associated BO may therefore develop following M. pneumonia bronchiolitis and overlap with asthma.
format	article
author	Chengsong Zhao Jinrong Liu Haiming Yang Li Xiang Shunying Zhao
author_facet	Chengsong Zhao Jinrong Liu Haiming Yang Li Xiang Shunying Zhao
author_sort	Chengsong Zhao
title	Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis
title_short	Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis
title_full	Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis
title_fullStr	Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis
title_full_unstemmed	Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis
title_sort	mycoplasma pneumoniae–associated bronchiolitis obliterans following acute bronchiolitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4f94283f7ac843f0974472fc6772a349
work_keys_str_mv	AT chengsongzhao mycoplasmapneumoniaeassociatedbronchiolitisobliteransfollowingacutebronchiolitis AT jinrongliu mycoplasmapneumoniaeassociatedbronchiolitisobliteransfollowingacutebronchiolitis AT haimingyang mycoplasmapneumoniaeassociatedbronchiolitisobliteransfollowingacutebronchiolitis AT lixiang mycoplasmapneumoniaeassociatedbronchiolitisobliteransfollowingacutebronchiolitis AT shunyingzhao mycoplasmapneumoniaeassociatedbronchiolitisobliteransfollowingacutebronchiolitis
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Mycoplasma pneumoniae–Associated Bronchiolitis Obliterans Following Acute Bronchiolitis

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