A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories

Abstract Exposure to a novel environment can enhance the extinction of recent contextual fear in mice. This has been explained by a tagging and capture hypothesis. Consistently, we show in mice that exposure to a novel environment before extinction training promoted the extinction of recent auditory...

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Autores principales:	Fulian Huang, Guangjing Zou, Can Li, Hui Meng, Xiaoyan Liu, Zehua Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4f94635df6564eb0a6359afbae1e6e0f
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spelling	oai:doaj.org-article:4f94635df6564eb0a6359afbae1e6e0f2021-12-02T10:59:18ZA novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories10.1038/s41598-020-60176-22045-2322https://doaj.org/article/4f94635df6564eb0a6359afbae1e6e0f2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-60176-2https://doaj.org/toc/2045-2322Abstract Exposure to a novel environment can enhance the extinction of recent contextual fear in mice. This has been explained by a tagging and capture hypothesis. Consistently, we show in mice that exposure to a novel environment before extinction training promoted the extinction of recent auditory fear. However, such a promoting effect of novelty was absent for remote memories. In the present study, we replaced the regular extinction training with a retrieval-extinction session which capitalized on a reconsolidation window. When novelty exposure was followed by a retrieval-extinction session, remote fear was distinguished more easily and permanently. We have termed it as a “novelty-retrieval-extinction” paradigm. This paradigm played a greater role in the extinction of remote fear when fear conditioning and retrieval-extinction occurred in two different contexts other than in one identical context. The mechanism underlying the facilitating effect of this paradigm might involve up-regulation of histone acetylation in the hippocampus, which has been reported to increase functional and structural neuroplasticity. The present work proposes an effective, drug-free paradigm for the extinction of remote fear, which could be easily adapted in humans with least side effects.Fulian HuangGuangjing ZouCan LiHui MengXiaoyan LiuZehua YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fulian Huang Guangjing Zou Can Li Hui Meng Xiaoyan Liu Zehua Yang A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
description	Abstract Exposure to a novel environment can enhance the extinction of recent contextual fear in mice. This has been explained by a tagging and capture hypothesis. Consistently, we show in mice that exposure to a novel environment before extinction training promoted the extinction of recent auditory fear. However, such a promoting effect of novelty was absent for remote memories. In the present study, we replaced the regular extinction training with a retrieval-extinction session which capitalized on a reconsolidation window. When novelty exposure was followed by a retrieval-extinction session, remote fear was distinguished more easily and permanently. We have termed it as a “novelty-retrieval-extinction” paradigm. This paradigm played a greater role in the extinction of remote fear when fear conditioning and retrieval-extinction occurred in two different contexts other than in one identical context. The mechanism underlying the facilitating effect of this paradigm might involve up-regulation of histone acetylation in the hippocampus, which has been reported to increase functional and structural neuroplasticity. The present work proposes an effective, drug-free paradigm for the extinction of remote fear, which could be easily adapted in humans with least side effects.
format	article
author	Fulian Huang Guangjing Zou Can Li Hui Meng Xiaoyan Liu Zehua Yang
author_facet	Fulian Huang Guangjing Zou Can Li Hui Meng Xiaoyan Liu Zehua Yang
author_sort	Fulian Huang
title	A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
title_short	A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
title_full	A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
title_fullStr	A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
title_full_unstemmed	A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
title_sort	novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4f94635df6564eb0a6359afbae1e6e0f
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A novelty-retrieval-extinction paradigm leads to persistent attenuation of remote fear memories

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