Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice

The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal that the X-chromosome-encoded miRNAs show low...

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Autores principales:	Chengqing Hu, Jiangcheng Shi, Yujing Chi, Jichun Yang, Qinghua Cui
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	X-chromosome-bearing sperm Y-chromosome-bearing sperm sex chromosome Science Q
Acceso en línea:	https://doaj.org/article/4f94809d4c074279b080ff0167bf9bca
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id	oai:doaj.org-article:4f94809d4c074279b080ff0167bf9bca
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spelling	oai:doaj.org-article:4f94809d4c074279b080ff0167bf9bca2021-11-25T18:11:18ZY/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice10.3390/life111112192075-1729https://doaj.org/article/4f94809d4c074279b080ff0167bf9bca2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1219https://doaj.org/toc/2075-1729The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal that the X-chromosome-encoded miRNAs show lower expression levels in the left testis than in the right testis in healthy mice using bioinformatics modeling of miRNA-sequencing data, suggesting that the Y:X ratio could be unbalanced between the left testis and the right testis. We further reveal that the Y:X ratio is significantly elevated in the left testis but balanced in the right testis using flow cytometry. This study represents the first time the biased Y:X ratio in the left testis but not in the right testis is revealed.Chengqing HuJiangcheng ShiYujing ChiJichun YangQinghua CuiMDPI AGarticleX-chromosome-bearing spermY-chromosome-bearing spermsex chromosomeScienceQENLife, Vol 11, Iss 1219, p 1219 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	X-chromosome-bearing sperm Y-chromosome-bearing sperm sex chromosome Science Q
spellingShingle	X-chromosome-bearing sperm Y-chromosome-bearing sperm sex chromosome Science Q Chengqing Hu Jiangcheng Shi Yujing Chi Jichun Yang Qinghua Cui Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice
description	The sex chromosomes play central roles in determining the sex of almost all of the multicellular organisms. It is well known that meiosis in mammalian spermatogenesis produces ~50% Y- and ~50% X-chromosome-bearing sperm, a 1:1 ratio. Here we first reveal that the X-chromosome-encoded miRNAs show lower expression levels in the left testis than in the right testis in healthy mice using bioinformatics modeling of miRNA-sequencing data, suggesting that the Y:X ratio could be unbalanced between the left testis and the right testis. We further reveal that the Y:X ratio is significantly elevated in the left testis but balanced in the right testis using flow cytometry. This study represents the first time the biased Y:X ratio in the left testis but not in the right testis is revealed.
format	article
author	Chengqing Hu Jiangcheng Shi Yujing Chi Jichun Yang Qinghua Cui
author_facet	Chengqing Hu Jiangcheng Shi Yujing Chi Jichun Yang Qinghua Cui
author_sort	Chengqing Hu
title	Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice
title_short	Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice
title_full	Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice
title_fullStr	Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice
title_full_unstemmed	Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice
title_sort	y/x-chromosome-bearing sperm shows elevated ratio in the left but not the right testes in healthy mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f94809d4c074279b080ff0167bf9bca
work_keys_str_mv	AT chengqinghu yxchromosomebearingspermshowselevatedratiointheleftbutnottherighttestesinhealthymice AT jiangchengshi yxchromosomebearingspermshowselevatedratiointheleftbutnottherighttestesinhealthymice AT yujingchi yxchromosomebearingspermshowselevatedratiointheleftbutnottherighttestesinhealthymice AT jichunyang yxchromosomebearingspermshowselevatedratiointheleftbutnottherighttestesinhealthymice AT qinghuacui yxchromosomebearingspermshowselevatedratiointheleftbutnottherighttestesinhealthymice
_version_	1718411496990441472

Y/X-Chromosome-Bearing Sperm Shows Elevated Ratio in the Left but Not the Right Testes in Healthy Mice

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