Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link

Sleep Disordered Breathing (SDB) and Alzheimer’s Disease (AD) are strongly associated clinically, but it is unknown if they are mechanistically associated. Here, we review data covering both the cellular and molecular responses in SDB and AD with an emphasis on the overlapping neuroimmune responses...

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Autores principales:	Tyler K. Ulland, Andrea C. Ewald, Andrew O. Knutson, Kaitlyn M. Marino, Stephanie M. C. Smith, Jyoti J. Watters
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuroinflammation intermittent hypoxia inflammasome animal models sexual dimorphism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4f95946fd33740389127b7fe8b7aaba2
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spelling	oai:doaj.org-article:4f95946fd33740389127b7fe8b7aaba22021-11-25T17:08:46ZAlzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link10.3390/cells101129072073-4409https://doaj.org/article/4f95946fd33740389127b7fe8b7aaba22021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2907https://doaj.org/toc/2073-4409Sleep Disordered Breathing (SDB) and Alzheimer’s Disease (AD) are strongly associated clinically, but it is unknown if they are mechanistically associated. Here, we review data covering both the cellular and molecular responses in SDB and AD with an emphasis on the overlapping neuroimmune responses in both diseases. We extensively discuss the use of animal models of both diseases and their relative utilities in modeling human disease. Data presented here from mice exposed to intermittent hypoxia indicate that microglia become more activated following exposure to hypoxia. This also supports the idea that intermittent hypoxia can activate the neuroimmune system in a manner like that seen in AD. Finally, we highlight similarities in the cellular and neuroimmune responses between SDB and AD and propose that these similarities may lead to a pathological synergy between SDB and AD.Tyler K. UllandAndrea C. EwaldAndrew O. KnutsonKaitlyn M. MarinoStephanie M. C. SmithJyoti J. WattersMDPI AGarticleneuroinflammationintermittent hypoxiainflammasomeanimal modelssexual dimorphismBiology (General)QH301-705.5ENCells, Vol 10, Iss 2907, p 2907 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroinflammation intermittent hypoxia inflammasome animal models sexual dimorphism Biology (General) QH301-705.5
spellingShingle	neuroinflammation intermittent hypoxia inflammasome animal models sexual dimorphism Biology (General) QH301-705.5 Tyler K. Ulland Andrea C. Ewald Andrew O. Knutson Kaitlyn M. Marino Stephanie M. C. Smith Jyoti J. Watters Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
description	Sleep Disordered Breathing (SDB) and Alzheimer’s Disease (AD) are strongly associated clinically, but it is unknown if they are mechanistically associated. Here, we review data covering both the cellular and molecular responses in SDB and AD with an emphasis on the overlapping neuroimmune responses in both diseases. We extensively discuss the use of animal models of both diseases and their relative utilities in modeling human disease. Data presented here from mice exposed to intermittent hypoxia indicate that microglia become more activated following exposure to hypoxia. This also supports the idea that intermittent hypoxia can activate the neuroimmune system in a manner like that seen in AD. Finally, we highlight similarities in the cellular and neuroimmune responses between SDB and AD and propose that these similarities may lead to a pathological synergy between SDB and AD.
format	article
author	Tyler K. Ulland Andrea C. Ewald Andrew O. Knutson Kaitlyn M. Marino Stephanie M. C. Smith Jyoti J. Watters
author_facet	Tyler K. Ulland Andrea C. Ewald Andrew O. Knutson Kaitlyn M. Marino Stephanie M. C. Smith Jyoti J. Watters
author_sort	Tyler K. Ulland
title	Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
title_short	Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
title_full	Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
title_fullStr	Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
title_full_unstemmed	Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link
title_sort	alzheimer’s disease, sleep disordered breathing, and microglia: puzzling out a common link
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4f95946fd33740389127b7fe8b7aaba2
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Alzheimer’s Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link

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